{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["209(8)"],"submitter":["Peaudecerf L"],"pubmed_abstract":["Thymus transplants can correct deficiencies of the thymus epithelium caused by the complete DiGeorge syndrome or FOXN1 mutations. However, thymus transplants were never used to correct T cell-intrinsic deficiencies because it is generally believed that thymocytes have short intrinsic lifespans. This notion is based on thymus transplantation experiments where it was shown that thymus-resident cells were rapidly replaced by progenitors originating in the bone marrow. In contrast, here we show that neonatal thymi transplanted into interleukin 7 receptor-deficient hosts harbor populations with extensive capacity to self-renew, and maintain continuous thymocyte generation and export. These thymus transplants reconstitute the full diversity of peripheral T cell repertoires one month after surger"],"journal":["The Journal of experimental medicine"],"pagination":["1401-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3420331"],"repository":["biostudies-literature"],"pubmed_title":["Thymocytes may persist and differentiate without any input from bone marrow progenitors."],"pmcid":["PMC3420331"],"pubmed_authors":["Vasseur F","Di Santo JP","Peaudecerf L","Galgano A","Ezine S","Krenn G","Lemos S","Rocha B"],"additional_accession":[]},"is_claimable":false,"name":"Thymocytes may persist and differentiate without any input from bone marrow progenitors.","description":"Thymus transplants can correct deficiencies of the thymus epithelium caused by the complete DiGeorge syndrome or FOXN1 mutations. However, thymus transplants were never used to correct T cell-intrinsic deficiencies because it is generally believed that thymocytes have short intrinsic lifespans. This notion is based on thymus transplantation experiments where it was shown that thymus-resident cells were rapidly replaced by progenitors originating in the bone marrow. In contrast, here we show that neonatal thymi transplanted into interleukin 7 receptor-deficient hosts harbor populations with extensive capacity to self-renew, and maintain continuous thymocyte generation and export. These thymus transplants reconstitute the full diversity of peripheral T cell repertoires one month after surger","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jul","modification":"2025-04-05T13:04:34.439Z","creation":"2019-03-27T00:56:49Z"},"accession":"S-EPMC3420331","cross_references":{"pubmed":["22778388"],"doi":["10.1084/jem.20120845"]}}