biostudies-literatureUnknown2012Oleaga C<h4>Background</h4>Epidemiological studies suggest that coffee consumption reduces the risk of cancer, but the molecular mechanisms of its chemopreventive effects remain unknown.<h4>Objective</h4>To identify differentially expressed genes upon incubation of HT29 colon cancer cells with instant caffeinated coffee (ICC) or caffeic acid (CA) using whole-genome microarrays.<h4>Results</h4>ICC incubation of HT29 cells caused the overexpression of 57 genes and the underexpression of 161, while CA incubation induced the overexpression of 12 genes and the underexpression of 32. Using Venn-Diagrams, we built a list of five overexpressed genes and twelve underexpressed genes in common between the two experimental conditions. This list was used to generate a biological association network in which STOxidative medicine and cellular longevity390385https://www.ebi.ac.uk/biostudies/studies/S-EPMC3424007biostudies-literatureCoffee polyphenols change the expression of STAT5B and ATF-2 modifying cyclin D1 levels in cancer cells.PMC3424007Izquierdo-Pulido MNoe VOleaga CCiudad CJfalseCoffee polyphenols change the expression of STAT5B and ATF-2 modifying cyclin D1 levels in cancer cells.<h4>Background</h4>Epidemiological studies suggest that coffee consumption reduces the risk of cancer, but the molecular mechanisms of its chemopreventive effects remain unknown.<h4>Objective</h4>To identify differentially expressed genes upon incubation of HT29 colon cancer cells with instant caffeinated coffee (ICC) or caffeic acid (CA) using whole-genome microarrays.<h4>Results</h4>ICC incubation of HT29 cells caused the overexpression of 57 genes and the underexpression of 161, while CA incubation induced the overexpression of 12 genes and the underexpression of 32. Using Venn-Diagrams, we built a list of five overexpressed genes and twelve underexpressed genes in common between the two experimental conditions. This list was used to generate a biological association network in which ST2012-01-01T00:00:00Z20122025-04-18T23:28:46.684Z2019-06-05T17:32:48ZS-EPMC34240072291943910.1155/2012/390385