biostudies-literatureUnknown7(8)Armstrong CABiotechnology and Biological Sciences Research CouncilThe ability of ionizing radiation to initiate genomic instability has been harnessed in the clinic where the localized delivery of controlled doses of radiation is used to induce cell death in tumor cells. Though very effective as a therapy, tumor relapse can occur in vivo and its appearance has been attributed to the radio-resistance of cells with stem cell-like features. The molecular mechanisms underlying these phenomena are unclear but there is evidence suggesting an inverse correlation between radiation-induced genomic instability and global hypomethylation. To further investigate the relationship between DNA hypomethylation, radiosensitivity and genomic stability in stem-like cells we have studied mouse embryonic stem cells containing differing levels of DNA methylation due to the prEpigenetics892-902https://www.ebi.ac.uk/biostudies/studies/S-EPMC3427285biostudies-literatureDNMTs are required for delayed genome instability caused by radiation.PMC3427285Armstrong CANarayanan DJones GDIyer PTufarelli CAnderson RSingh RTalbot CJSandhu JfalseDNMTs are required for delayed genome instability caused by radiation.The ability of ionizing radiation to initiate genomic instability has been harnessed in the clinic where the localized delivery of controlled doses of radiation is used to induce cell death in tumor cells. Though very effective as a therapy, tumor relapse can occur in vivo and its appearance has been attributed to the radio-resistance of cells with stem cell-like features. The molecular mechanisms underlying these phenomena are unclear but there is evidence suggesting an inverse correlation between radiation-induced genomic instability and global hypomethylation. To further investigate the relationship between DNA hypomethylation, radiosensitivity and genomic stability in stem-like cells we have studied mouse embryonic stem cells containing differing levels of DNA methylation due to the pr2012-01-01T00:00:00Z2012 Aug2025-07-12T03:06:09.215Z2025-07-12T03:06:09.215ZS-EPMC34272852272233110.4161/epi.21094