{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(8)"],"submitter":["Pieramico V"],"pubmed_abstract":["<h4>Background</h4>Aging is a major co-risk factor in many neurodegenerative diseases. Cognitive enrichment positively affects the structural plasticity of the aging brain. In this study, we evaluated effects of a set of structured multimodal activities (Combination Training; CT) on cognitive performances, functional connectivity, and cortical thickness of a group of healthy elderly individuals. CT lasted six months.<h4>Methodology</h4>Neuropsychological and occupational performances were evaluated before and at the end of the training period. fMRI was used to assess effects of training on resting state network (RSN) functional connectivity using Independent Component Analysis (ICA). Effects on cortical thickness were also studied. Finally, we evaluated whether specific dopamine-related ge"],"journal":["PloS one"],"pagination":["e43901"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3429431"],"repository":["biostudies-literature"],"pubmed_title":["Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes."],"pmcid":["PMC3429431"],"pubmed_authors":["Romani GL","Mattei PA","Gatta V","Frazzini V","Ferretti A","Sensi SL","Pieramico V","Sensi F","Ciavardelli D","Cilli F","Esposito R","Mantini D"],"additional_accession":[]},"is_claimable":false,"name":"Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.","description":"<h4>Background</h4>Aging is a major co-risk factor in many neurodegenerative diseases. Cognitive enrichment positively affects the structural plasticity of the aging brain. In this study, we evaluated effects of a set of structured multimodal activities (Combination Training; CT) on cognitive performances, functional connectivity, and cortical thickness of a group of healthy elderly individuals. CT lasted six months.<h4>Methodology</h4>Neuropsychological and occupational performances were evaluated before and at the end of the training period. fMRI was used to assess effects of training on resting state network (RSN) functional connectivity using Independent Component Analysis (ICA). Effects on cortical thickness were also studied. Finally, we evaluated whether specific dopamine-related ge","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2026-04-29T13:24:27.05Z","creation":"2025-07-02T03:05:01.404Z"},"accession":"S-EPMC3429431","cross_references":{"pubmed":["22937122"],"doi":["10.1371/journal.pone.0043901"]}}