{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pijpe A"],"funding":["Cancer Research UK","National Institute for Health Research (NIHR)","NCI NIH HHS"],"pagination":["e5660"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3435441"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["345"],"pubmed_abstract":["<h4>Objective</h4>To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations.<h4>Design</h4>Retrospective cohort study (GENE-RAD-RISK).<h4>Setting</h4>Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands,<h4>Participants</h4>1993 female carriers of BRCA1/2 mutations recruited in 2006-09.<h4>Main outcome measure</h4>Risk of breast cancer estimated with a weighted Cox proportional hazards model with a time dependent individually estimated cumulative breast dose, based on nominal estimates of organ dose and frequency of self reported diagnostic procedures. To correct for potential survival bias, the analysis excluded carriers who were diagnosed more than five years before completion of the study ques"],"journal":["BMJ (Clinical research ed.)"],"pubmed_title":["Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK)."],"pmcid":["PMC3435441"],"funding_grant_id":["10118","C5047/A8385","C1287/A8874","15007","11022","NF-SI-0510-10096","R01 CA142657"],"pubmed_authors":["Castro E","Peock S","Oliver C","Frost D","Vennin P","van der Hout A","Brohet R","van den Ouweland A","de Sienne C","Hughes L","Burgess L","Baxter L","Easton DF","Brewer C","Paterson J","Rossi A","Page E","Berthet P","Eeles RA","Gille H","Guimbaud R","Oosterwijk J","Ausems MG","Langman C","Cook M","Huiart L","Cook J","Thierry-Chef I","Goldgar D","Verhoef S","Miller J","Faivre L","Longy M","Lortholary A","Adenis C","EMBRACE","Chu C","Pichert G","Dugast C","Zattara-Cannoni H","Cole T","Wijnen J","Shenton A","Rookus MA","van Asperen CJ","Hooning M","Kesminiene A","GENEPSO","Schutte M","Side L","Bignon YJ","Houlston R","Sobol H","Kriege M","Fourme E","Hodgson S","Seynaeve C","Meijers-Heijboer H","Shanley S","Noruzinia M","Goff S","Tollenaar R","Lasset C","HEBON","Evans DG","Perrin J","Lidereau R","Cardis E","Bonadona V","Gauducheau R","Gladieff L","Andrieu N","Ausems M","Dreyfus H","van 't Veer L","van Leeuwen FE","Davidson R","Evans G","Gesta P","Rahman N","Chompret A","van Os T","Nogues C","Eccles D","Rookus M","Blok R","Izatt L","Chevrier A","Aalfs C","Nguyen TD","Bradshaw N","Ligtenberg M","van der Luijt R","Hogervorst F","Hauptmann M","Venat-Bouvet L","Manders P","Frenay M","Courlancy P","Rogers M","Fricker JP","Devilee P","Lalloo F","Luporsi E","van Asperen C","van Leeuwen F","van Leeuwen I","Demange L","Pijpe A","Gomez-Garcia E","Stevens D","Collee M","Bancroft E","Stoppa-Lyonnet D","Gregory H","Vasen H","Limacher JM","Gauthier-Villars M"],"additional_accession":[]},"is_claimable":false,"name":"Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK).","description":"<h4>Objective</h4>To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations.<h4>Design</h4>Retrospective cohort study (GENE-RAD-RISK).<h4>Setting</h4>Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands,<h4>Participants</h4>1993 female carriers of BRCA1/2 mutations recruited in 2006-09.<h4>Main outcome measure</h4>Risk of breast cancer estimated with a weighted Cox proportional hazards model with a time dependent individually estimated cumulative breast dose, based on nominal estimates of organ dose and frequency of self reported diagnostic procedures. To correct for potential survival bias, the analysis excluded carriers who were diagnosed more than five years before completion of the study ques","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Sep","modification":"2026-07-15T18:45:29.033Z","creation":"2026-07-09T03:08:19.727Z"},"accession":"S-EPMC3435441","cross_references":{"pubmed":["22956590"],"doi":["10.1136/bmj.e5660"]}}