{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["53(10)"],"submitter":["Awada M"],"pubmed_abstract":["Dietary intake of long-chain n-3 PUFA is now widely advised for public health and in medical practice. However, PUFA are highly prone to oxidation, producing potentially deleterious 4-hydroxy-2-alkenals. Even so, the impact of consuming oxidized n-3 PUFA on metabolic oxidative stress and inflammation is poorly described. We therefore studied such effects and hypothesized the involvement of the intestinal absorption of 4-hydroxy-2-hexenal (4-HHE), an oxidized n-3 PUFA end-product. In vivo, four groups of mice were fed for 8 weeks high-fat diets containing moderately oxidized or unoxidized n-3 PUFA. Other mice were orally administered 4-HHE and euthanized postprandially versus baseline mice. In vitro, human intestinal Caco-2/TC7 cells were incubated with 4-hydroxy-2-alkenals. Oxidized diets "],"journal":["Journal of lipid research"],"pagination":["2069-2080"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3435540"],"repository":["biostudies-literature"],"pubmed_title":["Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells."],"pmcid":["PMC3435540"],"pubmed_authors":["Meynier A","Michalski MC","Soulage CO","Estienne M","Genot C","Guichardant M","Lagarde M","Plaisancie P","Benoit B","Chauvin MA","Picard G","Debard C","Loizon E","Peretti N","Awada M"],"additional_accession":[]},"is_claimable":false,"name":"Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells.","description":"Dietary intake of long-chain n-3 PUFA is now widely advised for public health and in medical practice. However, PUFA are highly prone to oxidation, producing potentially deleterious 4-hydroxy-2-alkenals. Even so, the impact of consuming oxidized n-3 PUFA on metabolic oxidative stress and inflammation is poorly described. We therefore studied such effects and hypothesized the involvement of the intestinal absorption of 4-hydroxy-2-hexenal (4-HHE), an oxidized n-3 PUFA end-product. In vivo, four groups of mice were fed for 8 weeks high-fat diets containing moderately oxidized or unoxidized n-3 PUFA. Other mice were orally administered 4-HHE and euthanized postprandially versus baseline mice. In vitro, human intestinal Caco-2/TC7 cells were incubated with 4-hydroxy-2-alkenals. Oxidized diets ","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Oct","modification":"2025-04-18T18:26:37.805Z","creation":"2019-03-27T00:57:38Z"},"accession":"S-EPMC3435540","cross_references":{"pubmed":["22865918"],"doi":["10.1194/jlr.m026179","10.1194/jlr.M026179"]}}