biostudies-literatureFlorez JCNCATS NIH HHSNIDDK NIH HHSe44424https://www.ebi.ac.uk/biostudies/studies/S-EPMC3439414biostudies-literatureUnknown7(9)Common genetic variants have been recently associated with fasting glucose and insulin levels in white populations. Whether these associations replicate in pre-diabetes is not known. We extended these findings to the Diabetes Prevention Program, a clinical trial in which participants at high risk for diabetes were randomized to placebo, lifestyle modification or metformin for diabetes prevention. We genotyped previously reported polymorphisms (or their proxies) in/near G6PC2, MTNR1B, GCK, DGKB, GCKR, ADCY5, MADD, CRY2, ADRA2A, FADS1, PROX1, SLC2A2, GLIS3, C2CD4B, IGF1, and IRS1 in 3,548 Diabetes Prevention Program participants. We analyzed variants for association with baseline glycemic traits, incident diabetes and their interaction with response to metformin or lifestyle intervention. WePloS oneEffects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.PMC3439414UL1 TR000041P30 DK079637P30 DK017047R01 DK072041U01 DK048489U01DK048489UL1 TR001449Caro JFTestaverde LHorse EKellum TSmith CFBoggs GJohnson MKBrancati FLPercy CASmith CMSewenemewa JRoston SNgo KRochon JHeard DRyder LHorak KBray GAFrazier MTemprosa MDavid KFineberg ESVenditti EMau MKFisher ELiberoni RBamdad JWeinzierl VMontgomery BKMiller MMcLymont VMarrero DGMagpuri PSemler LSantiago ALovejoy JCSaab PHaffner SMUwaifo GAndre VLMcNabb WChai LMucik PNelson JAZimmerman EAtler LFGiannella ALyman MDiabetes Prevention Program Research GroupLambeth HApplegate WBBurge MRFarago MBarrett-Connor ELee JEMoran RRPolonsky KSFowler SSeely EWMikami KBallonoff LBRubin RRMohideen PSteinke SCHaffner LSherman ARMayer-Davis EJablonski KAPompi DGregg ELawton KEConzues CCallaghan JJanesch SSShuldiner ARPena MBTonemah DMartinez HFreel JPrineas RJLoman KMills MSaad MFMartinez ANashboo YLachin JMSherif HHernandez-McGinnis DAOldmixon CFLipkin EWDonahue RPBronsord MSullivan ECzech KGuillory FGAbbas CPrince MJJohnson DMason CCPrineas RKoenning GOlefsky JMReinhart RReidy MMendez JAnderson EOdom SKCanady JLWatson PGCassanova-Romero PHarris LGoldman VLarsen DFlorez JCSantiago JVPoulos ADuffy HMather KKahn SEHurt ESangster SRowe PMosley HRubtchinsky SMcAteer JBNair AKKnopp RHKobus KMCooeyate NYazzie MCook MGlass JArakaki RFKramer MGohdes DGlass MRyan DTurgeon HBegay SSeagle HJones TLImseis RPal CJinagouda SGaniats TCalles JLeos DVan Wye GERubinchik SLongchamp NStewart KJJeffirs MLKloiber SDotson YFVicknair PCRoach PJMalloy MABryant MHill JOMudaliar SJohnson CKFlorez HJCox LBarr SMendoza JBeddow RBissett LZonszein Jde Bakker PIGreenway FSarkin AJAllison DBJackson MLAdams KSBroussard BAGuare JCEdgerton CGao YBird ECEhrmann DPollin TIMullen MYoussef GRooney ESDas SAlexander TSchade DSGarfield SHoskin MAStrylewicz GMelancon LEFoo STWalker EFujimoto WGrant WSt Amant JAStamm EPerry RUEberhardt BSmith FEdelstein SLPerry ASmith JPan JJay PPoirier SAdorno ESmith MKula LMBenson MBWhite NHWing RRSoberman JEWilliams KVOtto ACalonge BCheatham WWGoldstein BJChampagne CMGoldberg RBMetzger BEJortberg BTRoumain JWilliams-Cleaves BAronoff NJDuncan RSemenske ARBryer-Ash MGanda OPKatz PAbbott KKatz RPepe CLorenzo CGilligan RHall SDelve LHorton ESBrown JOHenry RRCallaphan KMShapiro SKnowler WCNicosia MJohannes CAltshuler DSenter WWylie-Rosett JKitabchi AEJablonski KBradley VHoward-Century CJParkes KCola SSanford DARegensteiner JGJackson SDLevatan CKirby LPolonsky WLatimer RWGhahate JMSchweizer DHorne JMatulik MJRutledge LMOrchard TManus CBoraz MAldrich FCulbert IWMolitch MECarrion-Petersen MLOrlosky RTulley RTKirkman MSClifford LOktaei HHarrier SSchinleber PADacawyma TBehrends CLarreal CSapozhnikova AInouye JAbebe SKelly SMScheindlin JCulyba RFriedler ASaudek CDBrenneman TRassam AHoyer SRHadden AMEvans CTrence DLi YViscovich KANathan DMFitzgibbon MVanDorsten BFradkin JCrandall JJones SWarram JJones TAnderson DRJacobsen AMDelahanty LCaballero EMarr MRowland NDFranklin TMurphy MEPorter BDBain RTobian JGrover NJackson MWheeler MLDeSandre CSimonson DWalker-Murray FZhang ZKrakoff JMontez MGWilson TSamuels AZachwieja JJEdelman SVKocal MClark BHamman RFNoel AZhang PVejvoda KRatner RESmith LLGiles MMJeffries SHerbert AAKaskalla RSKerr MJiggetts DHorton ESolomon CGBurke JPCagliero EManjoo QPemberton NHanson RLDagogo-Jack SCharleston JBFranks PWShamoon HEngel SLichtermann LCKessler DWhittington TMarcovina SPitts TOjito JPrice DWKriska ARowse DEastman RPolczynski EWernimont CArky RAMcPherson DO'Leary DSmith KGMichaels SPi-Sunyer FWilson CGrimes KLActon KJLenz DSmith KAGibbs PRautaharju PHilbrich RBrown ASpandorfer JBarber RBrown ERautaharju FNash PVDabelea DPassaro MGoldberg RBudget MBouffard ALowe AClark JMIgnaut JMXapthalamous KHerman WHBoyle PJMorris LHStimpson CChavez MDoughty MSGonzales YWilliamson DQuitingon MWilliamson PCrandall JPBaker-Ladao NKFrieson SLBavido-Arrage CIngraham LEAkbar KMcKitrick CKing CViolino EKennedy BMMorgan TWaters DBennett PHCampbell CJoseph HDias LMather KJfalseEffects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.Common genetic variants have been recently associated with fasting glucose and insulin levels in white populations. Whether these associations replicate in pre-diabetes is not known. We extended these findings to the Diabetes Prevention Program, a clinical trial in which participants at high risk for diabetes were randomized to placebo, lifestyle modification or metformin for diabetes prevention. We genotyped previously reported polymorphisms (or their proxies) in/near G6PC2, MTNR1B, GCK, DGKB, GCKR, ADCY5, MADD, CRY2, ADRA2A, FADS1, PROX1, SLC2A2, GLIS3, C2CD4B, IGF1, and IRS1 in 3,548 Diabetes Prevention Program participants. We analyzed variants for association with baseline glycemic traits, incident diabetes and their interaction with response to metformin or lifestyle intervention. We2012-01-01T00:00:00Z20122026-04-29T13:50:02.396Z2026-04-07T15:15:21.004ZS-EPMC34394142298450610.1371/journal.pone.0044424