{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Filipowicz A"],"pubmed_abstract":["<h4>Background</h4>Bioconjugates of a polyamidoamine (PAMAM) G3 dendrimer and an aldehyde were synthesized as carriers for vitamins A and B₆, and the bioavailability of these vitamins for skin nutrition was investigated.<h4>Methods</h4>Nuclear magnetic resonance (NMR) and ultraviolet-visible methods were used to characterize the structure of the bioconjugates and for monitoring release of pyridoxal (Pyr) and pyridoxal phosphate (PLP) from these bioconjugates in vitro. A skin model permeation of bioconjugates was also studied in a Franz chamber.<h4>Results</h4>A transdermal G3 PAMAM dendrimer was used to synthesize bioconjugates with trans-retinal (Ret), pyridoxal (Pyr), or PLP. These nanomolecules, containing up to four covalently linked Ret, Pyr, or PLP (G3(4Ret), G3(4Pyr), and G3(4PLP)),"],"journal":["International journal of nanomedicine"],"pagination":["4819-28"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3439857"],"repository":["biostudies-literature"],"pubmed_title":["Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate."],"pmcid":["PMC3439857"],"pubmed_authors":["Filipowicz A","Wolowiec S"],"additional_accession":[]},"is_claimable":false,"name":"Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate.","description":"<h4>Background</h4>Bioconjugates of a polyamidoamine (PAMAM) G3 dendrimer and an aldehyde were synthesized as carriers for vitamins A and B₆, and the bioavailability of these vitamins for skin nutrition was investigated.<h4>Methods</h4>Nuclear magnetic resonance (NMR) and ultraviolet-visible methods were used to characterize the structure of the bioconjugates and for monitoring release of pyridoxal (Pyr) and pyridoxal phosphate (PLP) from these bioconjugates in vitro. A skin model permeation of bioconjugates was also studied in a Franz chamber.<h4>Results</h4>A transdermal G3 PAMAM dendrimer was used to synthesize bioconjugates with trans-retinal (Ret), pyridoxal (Pyr), or PLP. These nanomolecules, containing up to four covalently linked Ret, Pyr, or PLP (G3(4Ret), G3(4Pyr), and G3(4PLP)),","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2025-04-19T15:53:18.802Z","creation":"2019-03-27T00:57:50Z"},"accession":"S-EPMC3439857","cross_references":{"pubmed":["22973101"],"doi":["10.2147/IJN.S34175"]}}