biostudies-literatureUnknown7Filipowicz A<h4>Background</h4>Bioconjugates of a polyamidoamine (PAMAM) G3 dendrimer and an aldehyde were synthesized as carriers for vitamins A and B₆, and the bioavailability of these vitamins for skin nutrition was investigated.<h4>Methods</h4>Nuclear magnetic resonance (NMR) and ultraviolet-visible methods were used to characterize the structure of the bioconjugates and for monitoring release of pyridoxal (Pyr) and pyridoxal phosphate (PLP) from these bioconjugates in vitro. A skin model permeation of bioconjugates was also studied in a Franz chamber.<h4>Results</h4>A transdermal G3 PAMAM dendrimer was used to synthesize bioconjugates with trans-retinal (Ret), pyridoxal (Pyr), or PLP. These nanomolecules, containing up to four covalently linked Ret, Pyr, or PLP (G3(4Ret), G3(4Pyr), and G3(4PLP)),International journal of nanomedicine4819-28https://www.ebi.ac.uk/biostudies/studies/S-EPMC3439857biostudies-literatureBioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate.PMC3439857Filipowicz AWolowiec SfalseBioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate.<h4>Background</h4>Bioconjugates of a polyamidoamine (PAMAM) G3 dendrimer and an aldehyde were synthesized as carriers for vitamins A and B₆, and the bioavailability of these vitamins for skin nutrition was investigated.<h4>Methods</h4>Nuclear magnetic resonance (NMR) and ultraviolet-visible methods were used to characterize the structure of the bioconjugates and for monitoring release of pyridoxal (Pyr) and pyridoxal phosphate (PLP) from these bioconjugates in vitro. A skin model permeation of bioconjugates was also studied in a Franz chamber.<h4>Results</h4>A transdermal G3 PAMAM dendrimer was used to synthesize bioconjugates with trans-retinal (Ret), pyridoxal (Pyr), or PLP. These nanomolecules, containing up to four covalently linked Ret, Pyr, or PLP (G3(4Ret), G3(4Pyr), and G3(4PLP)),2012-01-01T00:00:00Z20122025-04-19T15:53:18.802Z2019-03-27T00:57:50ZS-EPMC34398572297310110.2147/IJN.S34175