biostudies-literatureZhao NNIDDK NIH HHS790-6https://www.ebi.ac.uk/biostudies/studies/S-EPMC3443545biostudies-literatureUnknown82(7)Although high serum levels of galactose-deficient IgA1 (an important biomarker of IgA nephropathy (IgAN)) are found in most patients with IgAN, their relationship to disease severity and progression remains unclear. To help clarify this we prospectively enrolled 275 patients with IgAN and followed them for a median of 47 months (range 12-96 months). Serum galactose-deficient IgA1 was measured at the time of diagnosis using a lectin-based ELISA, and renal survival was modeled using the Cox proportional hazards method. The serum levels of galactose-deficient IgA1 were higher in patients with IgAN compared to those in healthy controls. Importantly, in adjusted analysis, higher levels of galactose-deficient IgA1 were independently associated with a greater risk of deterioration in renal functiKidney internationalThe level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression.PMC3443545R01 DK082753DK078244DK083663K23 DK090207R01 DK078244R21 DK083663DK082753R56 DK078244Lv JZhao NLi YHou PNovak JZhang HKiryluk KMoldoveanu ZGharavi AGfalseThe level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression.Although high serum levels of galactose-deficient IgA1 (an important biomarker of IgA nephropathy (IgAN)) are found in most patients with IgAN, their relationship to disease severity and progression remains unclear. To help clarify this we prospectively enrolled 275 patients with IgAN and followed them for a median of 47 months (range 12-96 months). Serum galactose-deficient IgA1 was measured at the time of diagnosis using a lectin-based ELISA, and renal survival was modeled using the Cox proportional hazards method. The serum levels of galactose-deficient IgA1 were higher in patients with IgAN compared to those in healthy controls. Importantly, in adjusted analysis, higher levels of galactose-deficient IgA1 were independently associated with a greater risk of deterioration in renal functi2012-01-01T00:00:00Z2012 Oct2025-04-05T13:17:23.606Z2019-03-27T00:58:02ZS-EPMC34435452267388810.1038/ki.2012.197