{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Humphries LA"],"funding":["NICHD NIH HHS","NIAID NIH HHS","NCI NIH HHS"],"pagination":["e45276"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3445470"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(9)"],"pubmed_abstract":["<h4>Background</h4>The polarized reorganization of the T cell membrane and intracellular signaling molecules in response to T cell receptor (TCR) engagement has been implicated in the modulation of T cell development and effector responses. In siRNA-based studies Dlg1, a MAGUK scaffold protein and member of the Scribble polarity complex, has been shown to play a role in T cell polarity and TCR signal specificity, however the role of Dlg1 in T cell development and function in vivo remains unclear.<h4>Methodology/principal findings</h4>Here we present the combined data from three independently-derived dlg1-knockout mouse models; two germline deficient knockouts and one conditional knockout. While defects were not observed in T cell development, TCR-induced early phospho-signaling, actin-medi"],"journal":["PloS one"],"pubmed_title":["Characterization of in vivo Dlg1 deletion on T cell development and function."],"pmcid":["PMC3445470"],"funding_grant_id":["2-T32-AI-07323","P01 CA093615","R01-AI067253-10","R01 AI067253","T32-HD07516","T32 AI007323","T32 HD007516"],"pubmed_authors":["Round JL","Russell SM","Sacirbegovic F","Silva O","Tomassian T","Miceli MC","McMahon KA","Burkhardt JK","Takamiya K","Humphries LA","Humbert PO","Shaffer MH","Huganir RL"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of in vivo Dlg1 deletion on T cell development and function.","description":"<h4>Background</h4>The polarized reorganization of the T cell membrane and intracellular signaling molecules in response to T cell receptor (TCR) engagement has been implicated in the modulation of T cell development and effector responses. In siRNA-based studies Dlg1, a MAGUK scaffold protein and member of the Scribble polarity complex, has been shown to play a role in T cell polarity and TCR signal specificity, however the role of Dlg1 in T cell development and function in vivo remains unclear.<h4>Methodology/principal findings</h4>Here we present the combined data from three independently-derived dlg1-knockout mouse models; two germline deficient knockouts and one conditional knockout. While defects were not observed in T cell development, TCR-induced early phospho-signaling, actin-medi","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2026-04-20T03:17:20.733Z","creation":"2026-04-20T03:10:17.379Z"},"accession":"S-EPMC3445470","cross_references":{"pubmed":["23028902"],"doi":["10.1371/journal.pone.0045276"]}}