{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wikman H"],"funding":["European Research Council"],"pagination":["R49"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3446383"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["<h4>Introduction</h4>With the improvement of therapeutic options for the treatment of breast cancer, the development of brain metastases has become a major limitation to life expectancy in many patients. Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer.<h4>Methods</h4>Patterns of chromosomal aberrations in primary breast tumors and brain metastases were compared with array-comparative genetic hybridization (CGH). The most significant region was further characterized in more detail by microsatellite and gene-expression analysis, and finally, the possible target gene was screened for mutations.<h4>Results</h4>The array CGH results showed that brain metastases, in general, display similar chromosomal aberrations as do pr"],"journal":["Breast cancer research : BCR"],"pubmed_title":["Relevance of PTEN loss in brain metastasis formation in breast cancer patients."],"pmcid":["PMC3446383"],"funding_grant_id":["269081"],"pubmed_authors":["Uslar L","Benner C","Pantel K","Kemming D","Zapatka M","Westphal M","Muller V","Hohensee I","Wikman H","Sauter G","Glatzel M","Ylstra B","Wrage M","Eylmann K","Lamszus K","Detels N"],"additional_accession":[]},"is_claimable":false,"name":"Relevance of PTEN loss in brain metastasis formation in breast cancer patients.","description":"<h4>Introduction</h4>With the improvement of therapeutic options for the treatment of breast cancer, the development of brain metastases has become a major limitation to life expectancy in many patients. Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer.<h4>Methods</h4>Patterns of chromosomal aberrations in primary breast tumors and brain metastases were compared with array-comparative genetic hybridization (CGH). The most significant region was further characterized in more detail by microsatellite and gene-expression analysis, and finally, the possible target gene was screened for mutations.<h4>Results</h4>The array CGH results showed that brain metastases, in general, display similar chromosomal aberrations as do pr","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2026-04-07T13:59:05.654Z","creation":"2019-03-27T00:58:08Z"},"accession":"S-EPMC3446383","cross_references":{"pubmed":["22429330"],"doi":["10.1186/bcr3150"]}}