biostudies-literatureWikman HEuropean Research CouncilR49https://www.ebi.ac.uk/biostudies/studies/S-EPMC3446383biostudies-literatureUnknown14(2)<h4>Introduction</h4>With the improvement of therapeutic options for the treatment of breast cancer, the development of brain metastases has become a major limitation to life expectancy in many patients. Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer.<h4>Methods</h4>Patterns of chromosomal aberrations in primary breast tumors and brain metastases were compared with array-comparative genetic hybridization (CGH). The most significant region was further characterized in more detail by microsatellite and gene-expression analysis, and finally, the possible target gene was screened for mutations.<h4>Results</h4>The array CGH results showed that brain metastases, in general, display similar chromosomal aberrations as do prBreast cancer research : BCRRelevance of PTEN loss in brain metastasis formation in breast cancer patients.PMC3446383269081Uslar LBenner CPantel KKemming DZapatka MWestphal MMuller VHohensee IWikman HSauter GGlatzel MYlstra BWrage MEylmann KLamszus KDetels NfalseRelevance of PTEN loss in brain metastasis formation in breast cancer patients.<h4>Introduction</h4>With the improvement of therapeutic options for the treatment of breast cancer, the development of brain metastases has become a major limitation to life expectancy in many patients. Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer.<h4>Methods</h4>Patterns of chromosomal aberrations in primary breast tumors and brain metastases were compared with array-comparative genetic hybridization (CGH). The most significant region was further characterized in more detail by microsatellite and gene-expression analysis, and finally, the possible target gene was screened for mutations.<h4>Results</h4>The array CGH results showed that brain metastases, in general, display similar chromosomal aberrations as do pr2012-01-01T00:00:00Z2012 Mar2026-04-07T13:59:05.654Z2019-03-27T00:58:08ZS-EPMC34463832242933010.1186/bcr3150