biostudies-literatureUnknown14(2)Bossini-Castillo L<h4>Introduction</h4>CD226 genetic variants have been associated with a number of autoimmune diseases and recently with systemic sclerosis (SSc). The aim of this study was to test the influence of CD226 loci in SSc susceptibility, clinical phenotypes and autoantibody status in a large multicenter European population.<h4>Methods</h4>A total of seven European populations of Caucasian ancestry were included, comprising 2,131 patients with SSc and 3,966 healthy controls. Three CD226 single nucleotide polymorphisms (SNPs), rs763361, rs3479968 and rs727088, were genotyped using Taqman 5'allelic discrimination assays.<h4>Results</h4>Pooled analyses showed no evidence of association of the three SNPs, neither with the global disease nor with the analyzed subphenotypes. However, haplotype block anaArthritis research & therapyR85https://www.ebi.ac.uk/biostudies/studies/S-EPMC3446459biostudies-literatureA multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis.PMC3446459Sanchez-Roman JKreuter ACastillo MJOrtego-Centeno NGonzalez-Gay MAde la Pena PGSaez-Comet Lvan Laar JMMartin JFernandez-Nebro ATolosa CNarvaez JLunardi CGomez-Gracia Ide Castro MFLopez-Longo FJCamps MTVonk MCWitte TBossini-Castillo LRios-Fernandez RGarcia-Hernandez FJAndreu JLGonzalez-Escribano MFMartinez LDenton CPNavarrete NSchuerwegh AJVaqueiro IGallego MSimeon CPBeltran ERadstake TRDiaz FCastellvi IHoffmann-Vold AMEgurbide MVEspinosa GDiaz BRoman-Ivorra JABeretta LPortales RGCarreira PAguirre MAFernandez-Gutierrez BRodriguez-Rodriguez LChee MMdel Rocio VBroen JCKoeleman BPTrapiella LPros AHesselstrand RFonollosa VHernandez VCallejas JLCarmen Freire MdHerrick ASpanish Scleroderma GroupFonseca CCarballeira MRfalseA multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis.<h4>Introduction</h4>CD226 genetic variants have been associated with a number of autoimmune diseases and recently with systemic sclerosis (SSc). The aim of this study was to test the influence of CD226 loci in SSc susceptibility, clinical phenotypes and autoantibody status in a large multicenter European population.<h4>Methods</h4>A total of seven European populations of Caucasian ancestry were included, comprising 2,131 patients with SSc and 3,966 healthy controls. Three CD226 single nucleotide polymorphisms (SNPs), rs763361, rs3479968 and rs727088, were genotyped using Taqman 5'allelic discrimination assays.<h4>Results</h4>Pooled analyses showed no evidence of association of the three SNPs, neither with the global disease nor with the analyzed subphenotypes. However, haplotype block ana2012-01-01T00:00:00Z2012 Apr2026-04-07T18:28:42.995Z2019-03-27T00:58:08ZS-EPMC34464592253149910.1186/ar3809