biostudies-literatureAjani JARiver Creek FoundationKevin FundAnderson&apos;s Cancer Center SupportMultidisciplinary Research Program at MD Anderson Cancer CenterAaron and Martha Schecter Private FoundationNCI NIH HHSNational Institutes of HealthDallas, Park, Smith, and Cantu family fundsSultan Fund2638-2642https://www.ebi.ac.uk/biostudies/studies/S-EPMC3457750biostudies-literatureUnknown23(10)<h4>Background</h4>Approximately 25% of patients with esophageal cancer (EC) who undergo preoperative chemoradiation, achieve a pathologic complete response (pathCR). We hypothesized that a model based on clinical parameters could predict pathCR with a high (≥60%) probability.<h4>Patients and methods</h4>We analyzed 322 patients with EC who underwent preoperative chemoradiation. All the patients had baseline and postchemoradiation positron emission tomography (PET) and pre- and postchemoradiation endoscopic biopsy. Logistic regression models were used for analysis, and cross-validation via the bootstrap method was carried out to test the model.<h4>Results</h4>The 70 (21.7%) patients who achieved a pathCR lived longer (median overall survival [OS], 79.76 months) than the 252 patients who diAnnals of oncology : official journal of the European Society for Medical OncologyClinical parameters model for predicting pathologic complete response following preoperative chemoradiation in patients with esophageal cancer.PMC3457750CA016672P30 CA016672Ajani JAWelsh JMacapinlac HARice DCLin SHMehran RJSwisher SGSuzuki AMaru DMVaporciyan AACorrea AMBhutani MSTaketa TBlum MAHofstetter WLKomaki RErasmus JLee JHRoss WAfalseClinical parameters model for predicting pathologic complete response following preoperative chemoradiation in patients with esophageal cancer.<h4>Background</h4>Approximately 25% of patients with esophageal cancer (EC) who undergo preoperative chemoradiation, achieve a pathologic complete response (pathCR). We hypothesized that a model based on clinical parameters could predict pathCR with a high (≥60%) probability.<h4>Patients and methods</h4>We analyzed 322 patients with EC who underwent preoperative chemoradiation. All the patients had baseline and postchemoradiation positron emission tomography (PET) and pre- and postchemoradiation endoscopic biopsy. Logistic regression models were used for analysis, and cross-validation via the bootstrap method was carried out to test the model.<h4>Results</h4>The 70 (21.7%) patients who achieved a pathCR lived longer (median overall survival [OS], 79.76 months) than the 252 patients who di2012-01-01T00:00:00Z2012 Oct2025-04-04T12:04:51.652Z2019-03-27T00:58:21ZS-EPMC34577502283198510.1093/annonc/mds210