{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Arisawa T"],"pubmed_abstract":["<h4>Background</h4>CpG island aberrant methylation is shown to be an important mechanism in gene silencing. The important role of IL-17 in inflammatory response to H. pylori colonization has been indicated. We investigated the influence of IL17A polymorphisms, -197 G > A (rs2275913) and *1249 C > T (rs3748067), on the methylation of DAPK and CDH1.<h4>Methods</h4>Gastric mucosal samples were obtained from 401 subjects without malignancies. Methylation status of gene was determined by MSP. The genotyping of IL17A was performed by PCR-SSCP.<h4>Results</h4>Methylations of DAPK and CDH1 were seen in 196 and 149 of all 401 subjects, respectively. Overall, *1249 T carrier was associated with a decreased risk for DAPK methylation, whereas -197 G > A was not. In the subjects older than 60 years old"],"journal":["BMC medical genetics"],"pagination":["59"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3458965"],"repository":["biostudies-literature"],"pubmed_title":["Influence of IL17A polymorphisms on the aberrant methylation of DAPK and CDH1 in non-cancerous gastric mucosa."],"pmcid":["PMC3458965"],"pubmed_authors":["Arisawa T","Shibata T","Tahara T","Tsutsumi M"],"additional_accession":[]},"is_claimable":false,"name":"Influence of IL17A polymorphisms on the aberrant methylation of DAPK and CDH1 in non-cancerous gastric mucosa.","description":"<h4>Background</h4>CpG island aberrant methylation is shown to be an important mechanism in gene silencing. The important role of IL-17 in inflammatory response to H. pylori colonization has been indicated. We investigated the influence of IL17A polymorphisms, -197 G > A (rs2275913) and *1249 C > T (rs3748067), on the methylation of DAPK and CDH1.<h4>Methods</h4>Gastric mucosal samples were obtained from 401 subjects without malignancies. Methylation status of gene was determined by MSP. The genotyping of IL17A was performed by PCR-SSCP.<h4>Results</h4>Methylations of DAPK and CDH1 were seen in 196 and 149 of all 401 subjects, respectively. Overall, *1249 T carrier was associated with a decreased risk for DAPK methylation, whereas -197 G > A was not. In the subjects older than 60 years old","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jul","modification":"2025-04-04T03:44:49.22Z","creation":"2019-06-05T17:41:28Z"},"accession":"S-EPMC3458965","cross_references":{"pubmed":["22827846"],"doi":["10.1186/1471-2350-13-59"]}}