{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(19)"],"submitter":["Gupta A"],"pubmed_abstract":["Lipid and protein tyrosine phosphatase, phosphatase and tension homologue (PTEN), is a widely known negative regulator of insulin/phosphoinositide 3-kinase signaling. Down-regulation of PTEN is thus widely documented to ameliorate insulin resistance in peripheral tissues such as skeletal muscle and adipose. However, not much is known about its exact role in neuronal insulin signaling and insulin resistance. Moreover, alterations of PTEN in neuronal systems have led to discovery of several unexpected outcomes, including in the neurodegenerative disorder Alzheimer's disease (AD), which is increasingly being recognized as a brain-specific form of diabetes. In addition, contrary to expectations, its neuron-specific deletion in mice resulted in development of diet-sensitive obesity. The present"],"journal":["Molecular biology of the cell"],"pagination":["3882-98"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3459864"],"repository":["biostudies-literature"],"pubmed_title":["PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance."],"pmcid":["PMC3459864"],"pubmed_authors":["Gupta A","Dey CS"],"additional_accession":[]},"is_claimable":false,"name":"PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance.","description":"Lipid and protein tyrosine phosphatase, phosphatase and tension homologue (PTEN), is a widely known negative regulator of insulin/phosphoinositide 3-kinase signaling. Down-regulation of PTEN is thus widely documented to ameliorate insulin resistance in peripheral tissues such as skeletal muscle and adipose. However, not much is known about its exact role in neuronal insulin signaling and insulin resistance. Moreover, alterations of PTEN in neuronal systems have led to discovery of several unexpected outcomes, including in the neurodegenerative disorder Alzheimer's disease (AD), which is increasingly being recognized as a brain-specific form of diabetes. In addition, contrary to expectations, its neuron-specific deletion in mice resulted in development of diet-sensitive obesity. The present","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Oct","modification":"2025-04-04T12:06:14.794Z","creation":"2019-03-27T00:58:28Z"},"accession":"S-EPMC3459864","cross_references":{"pubmed":["22875989"],"doi":["10.1091/mbc.E12-05-0337"]}}