{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(11)"],"submitter":["Roberti MP"],"pubmed_abstract":["Triple negative breast cancers (TNBC) lacking hormone receptors and HER-2 amplification are very aggressive tumors. Since relevant differences between primary tumors and metastases could arise during tumor progression as evidenced by phenotypic discordances reported for hormonal receptors or HER-2 expression, in this analysis we studied changes that occurred in our TNBC model IIB-BR-G throughout the development of IIB-BR-G-MTS6 metastasis to the lymph nodes (LN) in nude mice, using an antibody-based protein array to characterize their expression profile. We also analyzed their growth kinetics, migration, invasiveness and cytoskeleton structure in vitro and in vivo.   In vitro IIB-BR-G-MTS6 cells grew slower but showed higher anchorage independent growth. In vivo IIB-BR-G-MTS6 tumors grew s"],"journal":["Cancer biology & therapy"],"pagination":["1123-40"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3461818"],"repository":["biostudies-literature"],"pubmed_title":["Protein expression changes during human triple negative breast cancer cell line progression to lymph node metastasis in a xenografted model in nude mice."],"pmcid":["PMC3461818"],"pubmed_authors":["Arriaga JM","Bravo AI","Levy EM","Quinta HR","Bianchini M","Roberti MP","Barrio MM","Mordoh J"],"additional_accession":[]},"is_claimable":false,"name":"Protein expression changes during human triple negative breast cancer cell line progression to lymph node metastasis in a xenografted model in nude mice.","description":"Triple negative breast cancers (TNBC) lacking hormone receptors and HER-2 amplification are very aggressive tumors. Since relevant differences between primary tumors and metastases could arise during tumor progression as evidenced by phenotypic discordances reported for hormonal receptors or HER-2 expression, in this analysis we studied changes that occurred in our TNBC model IIB-BR-G throughout the development of IIB-BR-G-MTS6 metastasis to the lymph nodes (LN) in nude mice, using an antibody-based protein array to characterize their expression profile. We also analyzed their growth kinetics, migration, invasiveness and cytoskeleton structure in vitro and in vivo.   In vitro IIB-BR-G-MTS6 cells grew slower but showed higher anchorage independent growth. In vivo IIB-BR-G-MTS6 tumors grew s","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Sep","modification":"2025-07-03T03:04:46.075Z","creation":"2025-07-03T03:04:46.075Z"},"accession":"S-EPMC3461818","cross_references":{"pubmed":["22825326"],"doi":["10.4161/cbt.21187"]}}