{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(10)"],"submitter":["Zhao B"],"pubmed_abstract":["Protein that interacts with C kinase 1 (PICK1) is a critical mediator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking in neural synapses. However, its ubiquitous expression suggests that it may have other non-neural functions. Here we show that PICK1 antagonizes transforming growth factor beta (TGF-β) signaling by targeting TGF-β type I receptor (TβRI) for degradation. Biochemical analyses reveal that PICK1 directly interacts with the C-terminus of TβRI via its PDZ domain and acts as a scaffold protein to enhance the interaction between TβRI and caveolin-1, leading to enhanced lipid raft/caveolae localization. Therefore, PICK1 increases caveolin-mediated endocytosis, ubiquitination and degradation of TβRI. Moreover, a negative correlation between PICK1 "],"journal":["Cell research"],"pagination":["1467-78"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3463259"],"repository":["biostudies-literature"],"pubmed_title":["PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor."],"pmcid":["PMC3463259"],"pubmed_authors":["Xia J","Wang Q","Zhao B","Du J","Chen YG","Luo S"],"additional_accession":[]},"is_claimable":false,"name":"PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor.","description":"Protein that interacts with C kinase 1 (PICK1) is a critical mediator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking in neural synapses. However, its ubiquitous expression suggests that it may have other non-neural functions. Here we show that PICK1 antagonizes transforming growth factor beta (TGF-β) signaling by targeting TGF-β type I receptor (TβRI) for degradation. Biochemical analyses reveal that PICK1 directly interacts with the C-terminus of TβRI via its PDZ domain and acts as a scaffold protein to enhance the interaction between TβRI and caveolin-1, leading to enhanced lipid raft/caveolae localization. Therefore, PICK1 increases caveolin-mediated endocytosis, ubiquitination and degradation of TβRI. Moreover, a negative correlation between PICK1 ","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Oct","modification":"2025-07-03T03:04:47.249Z","creation":"2025-07-03T03:04:47.249Z"},"accession":"S-EPMC3463259","cross_references":{"pubmed":["22710801"],"doi":["10.1038/cr.2012.92"]}}