{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang C"],"funding":["NIGMS NIH HHS","CIHR"],"pagination":["505-21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3466600"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["241(3)"],"pubmed_abstract":["<h4>Background</h4>For a stem cell population to exist over an extended period, a balance must be maintained between self-renewing (proliferating) and differentiating daughter cells. Within the Caenorhabditis elegans germ line, this balance is controlled by a genetic regulatory pathway, which includes the canonical Notch signaling pathway.<h4>Results</h4>Genetic screens identified the gene teg-1 as being involved in regulating the proliferation versus differentiation decision in the C. elegans germ line. Cloning of TEG-1 revealed that it is a homolog of mammalian CD2BP2, which has been implicated in a number of cellular processes, including in U4/U6.U5 tri-snRNP formation in the pre-mRNA splicing reaction. The position of teg-1 in the genetic pathway regulating the proliferation versus dif"],"journal":["Developmental dynamics : an official publication of the American Association of Anatomists"],"pubmed_title":["TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor."],"pmcid":["PMC3466600"],"funding_grant_id":["R01 GM063310","GM63310"],"pubmed_authors":["Hansen D","Wang C","Schedl T","Wilson-Berry L"],"additional_accession":[]},"is_claimable":false,"name":"TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor.","description":"<h4>Background</h4>For a stem cell population to exist over an extended period, a balance must be maintained between self-renewing (proliferating) and differentiating daughter cells. Within the Caenorhabditis elegans germ line, this balance is controlled by a genetic regulatory pathway, which includes the canonical Notch signaling pathway.<h4>Results</h4>Genetic screens identified the gene teg-1 as being involved in regulating the proliferation versus differentiation decision in the C. elegans germ line. Cloning of TEG-1 revealed that it is a homolog of mammalian CD2BP2, which has been implicated in a number of cellular processes, including in U4/U6.U5 tri-snRNP formation in the pre-mRNA splicing reaction. The position of teg-1 in the genetic pathway regulating the proliferation versus dif","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2025-05-31T23:33:08.916Z","creation":"2025-05-31T23:33:08.916Z"},"accession":"S-EPMC3466600","cross_references":{"pubmed":["22275078"],"doi":["10.1002/dvdy.23735"]}}