{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aulicino PC"],"funding":["NIAID NIH HHS"],"pagination":["443-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3471996"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(2)"],"pubmed_abstract":["The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillanc"],"journal":["Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases"],"pubmed_title":["Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains."],"pmcid":["PMC3471996"],"funding_grant_id":["Y01 AI008309"],"pubmed_authors":["Mangano A","Foley B","Aulicino PC","Carr J","Sen L","Bello G","Gomez-Carrillo M","Rocco C"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains.","description":"The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillanc","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2026-04-07T16:05:57.269Z","creation":"2019-03-27T00:59:06Z"},"accession":"S-EPMC3471996","cross_references":{"pubmed":["22266022"],"doi":["10.1016/j.meegid.2012.01.003"]}}