biostudies-literatureAulicino PCNIAID NIH HHS443-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC3471996biostudies-literatureUnknown12(2)The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillancInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseasesCharacterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains.PMC3471996Y01 AI008309Mangano AFoley BAulicino PCCarr JSen LBello GGomez-Carrillo MRocco CfalseCharacterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains.The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillanc2012-01-01T00:00:00Z2012 Mar2026-04-07T16:05:57.269Z2019-03-27T00:59:06ZS-EPMC34719962226602210.1016/j.meegid.2012.01.003