{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(10)"],"submitter":["Ahamed M"],"funding":["Wellcome Trust"],"pubmed_abstract":["We compare the results from the oxidation of two unusual \"enediamide\" motifs (3,4-dihydropyrazin-2(1H)-ones), where a double bond is flanked by two amides. In one case the oxidation led to a ring-opened product arising from the cleavage of the double bond, and in the other a rare cis-dioxygenated compound was obtained. Both products have been characterized by X-ray crystallography. The outcomes of the key reactions are rationalized based on calculated free energies of intermediates."],"journal":["PloS one"],"pagination":["e47224"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3477162"],"repository":["biostudies-literature"],"pubmed_title":["The outcome of the oxidations of unusual enediamide motifs is governed by the stabilities of the intermediate iminium ions."],"pmcid":["PMC3477162"],"pubmed_authors":["Todd MH","Ahamed M","Jensen P","Chan B"],"additional_accession":[]},"is_claimable":false,"name":"The outcome of the oxidations of unusual enediamide motifs is governed by the stabilities of the intermediate iminium ions.","description":"We compare the results from the oxidation of two unusual \"enediamide\" motifs (3,4-dihydropyrazin-2(1H)-ones), where a double bond is flanked by two amides. In one case the oxidation led to a ring-opened product arising from the cleavage of the double bond, and in the other a rare cis-dioxygenated compound was obtained. Both products have been characterized by X-ray crystallography. The outcomes of the key reactions are rationalized based on calculated free energies of intermediates.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2021-02-20T15:11:14Z","creation":"2019-03-26T23:08:38Z"},"accession":"S-EPMC3477162","cross_references":{"pubmed":["23094038"],"doi":["10.1371/journal.pone.0047224"]}}