{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schmidt R"],"funding":["NIGMS NIH HHS"],"pagination":["251"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3491406"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(10)"],"pubmed_abstract":["Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome."],"journal":["Genome biology"],"pubmed_title":["The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation."],"pmcid":["PMC3491406"],"funding_grant_id":["T32 GM008042","P01 GM099134"],"pubmed_authors":["Schmidt R","Plath K"],"additional_accession":[]},"is_claimable":false,"name":"The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation.","description":"Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Oct","modification":"2025-04-04T07:41:42.794Z","creation":"2019-06-05T17:49:17Z"},"accession":"S-EPMC3491406","cross_references":{"pubmed":["23088445"],"doi":["10.1186/gb-2012-13-10-251"]}}