biostudies-literatureSchmidt RNIGMS NIH HHS251https://www.ebi.ac.uk/biostudies/studies/S-EPMC3491406biostudies-literatureUnknown13(10)Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome.Genome biologyThe roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation.PMC3491406T32 GM008042P01 GM099134Schmidt RPlath KfalseThe roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation.Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome.2012-01-01T00:00:00Z2012 Oct2025-04-04T07:41:42.794Z2019-06-05T17:49:17ZS-EPMC34914062308844510.1186/gb-2012-13-10-251