{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Han X"],"funding":["NCRR NIH HHS","NIGMS NIH HHS"],"pagination":["3808-11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3498537"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(14)"],"pubmed_abstract":["The classical geometry of the 6-endo transition state for nucleophilic additions into oxocarbenium ions can be perturbed by incorporating the reactive groups into medium-sized rings, leading to the formation of 2,6-trans-dialkyl tetrahydropyrans. The bicyclic products exhibit inside-outside stereoisomerism, as seen in numerous macrolide natural products."],"journal":["Organic letters"],"pubmed_title":["Synthesis of bridged inside-outside bicyclic ethers through oxidative transannular cyclization reactions."],"pmcid":["PMC3498537"],"funding_grant_id":["R01 GM062924","GM062924","1S10RR031789-01"],"pubmed_authors":["Floreancig PE","Han X"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of bridged inside-outside bicyclic ethers through oxidative transannular cyclization reactions.","description":"The classical geometry of the 6-endo transition state for nucleophilic additions into oxocarbenium ions can be perturbed by incorporating the reactive groups into medium-sized rings, leading to the formation of 2,6-trans-dialkyl tetrahydropyrans. The bicyclic products exhibit inside-outside stereoisomerism, as seen in numerous macrolide natural products.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jul","modification":"2025-04-04T01:06:21.946Z","creation":"2019-03-27T01:00:33Z"},"accession":"S-EPMC3498537","cross_references":{"pubmed":["22783950"],"doi":["10.1021/ol301720u"]}}