biostudies-literature001280Parkman HPNIDDK NIH HHS1056-64; quiz e133-4https://www.ebi.ac.uk/biostudies/studies/S-EPMC3499102biostudies-literatureUnknown9(12)<h4>Background & aims</h4>Gastroparesis can be diabetic or idiopathic, yet little is known about differences in their presentation. We compared clinical characteristics, symptoms, and gastric emptying in patients with type 1 or type 2 diabetic (DG) or idiopathic (IG) gastroparesis.<h4>Methods</h4>We analyzed data from 416 patients with gastroparesis who were enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Registry; 254 had IG (most were female and white), and 137 had DG (78 had type 1 and 59 had type 2). Registry data included detailed histories, physical examinations, results from gastric emptying scintigraphy, and responses to validated symptom questionnaires.<h4>Results</h4>Patients with type 2 diabetes mellitus (DM) were an average of 13 years older at the onset of symptoms of gastroparesis and heavier than patients with IG. Patients with type 1 DM had more hospitalizations in the past year than patients with IG. Symptoms that prompted evaluation more often included vomiting for DG and abdominal pain for IG. Patients with DG had more severe retching and vomiting than those with IG, whereas patients with IG had more severe early satiety and postprandial fullness subscores. Compared with IG, gastric retention was greater in patients with type 1 DM. More than 50% of patients with type 1 DM had severe retention (>35% at 4 hours); they took prokinetic agents more frequently and were more likely to receive gastric electric stimulation.<h4>Conclusions</h4>There are similarities and differences in clinical characteristics of DG and IG. Gastroparesis is a heterogeneous disorder; its etiology affects symptoms and severity. Long-term studies are needed to determine whether the differences in symptoms and gastric emptying affect progression and treatment responses.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological AssociationSimilarities and differences between diabetic and idiopathic gastroparesis.PMC3499102U01DK073975U01DK074008U01 DK074035U01 DK073975U01 DK074008U01DK073983U01 DK073983U01 DK074007U01DK074007U01 DK073985U01DK073985U01DK073974U01 DK073974Donithan MTonascia JMoody NChaithongdi NSternberg AYates KSaldana JAbell TSiraj EAmeen VWilson LTaylor MKirkeby KKantor SKoch KIsaacson MSnape WJDeVole NBaxter LJames SBasina MEarle KAbell TLDiseases KGreene MSarosiek IParker SPalit AConnery SBlock JCuller SFordham JVaughn IMinglana MSimmons KLytes VHejazi RMiriel LAtkinson MVan Raaphorst RClinton PStuart PHasler WHasler WLFarrugia GUelman SHamilton FVan Natta MLee LKedar ATorrance RPathikonda MMcNair VCalles JBright TKarstens ASnape WVega NMenon LNunan-Lui CHerman WRothberg AEMay PMcCallum RWPasricha PJUnalp-Arida ABuckingham BSachdeva PVasquez DNguyen LHomko CGreen MParkman HPKim WBernard CUllah NKoch KLHenry OBelt PNational Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research ConsortiumAmin OHooker J128falseSimilarities and differences between diabetic and idiopathic gastroparesis.<h4>Background & aims</h4>Gastroparesis can be diabetic or idiopathic, yet little is known about differences in their presentation. We compared clinical characteristics, symptoms, and gastric emptying in patients with type 1 or type 2 diabetic (DG) or idiopathic (IG) gastroparesis.<h4>Methods</h4>We analyzed data from 416 patients with gastroparesis who were enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Registry; 254 had IG (most were female and white), and 137 had DG (78 had type 1 and 59 had type 2). Registry data included detailed histories, physical examinations, results from gastric emptying scintigraphy, and responses to validated symptom questionnaires.<h4>Results</h4>Patients with type 2 diabetes mellitus (DM) were an average of 13 years older at the onset of symptoms of gastroparesis and heavier than patients with IG. Patients with type 1 DM had more hospitalizations in the past year than patients with IG. Symptoms that prompted evaluation more often included vomiting for DG and abdominal pain for IG. Patients with DG had more severe retching and vomiting than those with IG, whereas patients with IG had more severe early satiety and postprandial fullness subscores. Compared with IG, gastric retention was greater in patients with type 1 DM. More than 50% of patients with type 1 DM had severe retention (>35% at 4 hours); they took prokinetic agents more frequently and were more likely to receive gastric electric stimulation.<h4>Conclusions</h4>There are similarities and differences in clinical characteristics of DG and IG. Gastroparesis is a heterogeneous disorder; its etiology affects symptoms and severity. Long-term studies are needed to determine whether the differences in symptoms and gastric emptying affect progression and treatment responses.2011-01-01T00:00:00Z2011 Dec2024-11-05T22:17:34.779Z2019-03-27T01:00:34ZS-EPMC34991022187124710.1016/j.cgh.2011.08.013