biostudies-literatureAchat-Mendes CNIDA NIH HHSNCRR NIH HHSNIH HHS2837-45https://www.ebi.ac.uk/biostudies/studies/S-EPMC3499725biostudies-literatureUnknown37(13)Cognitive enhancers that act by increasing glycine transmission might be useful adjuncts to cocaine-cue extinction training to deter relapse. The study investigated the effects of combining treatments of the glycine transporter-1 (GlyT-1) inhibitor, Org24598, with extinction training on the subsequent reacquisition of cocaine self-administration. Squirrel monkeys and rats were trained to self-administer cocaine under a second-order schedule of intravenous drug injection in which responding was maintained by cocaine injections and a cocaine-paired visual stimulus. During three weekly extinction sessions, saline was substituted for cocaine but responding still produced the cocaine-paired stimulus. Subjects were treated with Org24598 or vehicle, either before or after each extinction session.Neuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyGlycine transporter-1 inhibition preceding extinction training inhibits reacquisition of cocaine seeking.PMC3499725K26 RR000168P51 OD011103DA024315-S1DA024315RR00168R01 DA024315P51 RR000168OD011103Achat-Mendes CNic Dhonnchadha BAPlatt DMSpealman RDKantak KMfalseGlycine transporter-1 inhibition preceding extinction training inhibits reacquisition of cocaine seeking.Cognitive enhancers that act by increasing glycine transmission might be useful adjuncts to cocaine-cue extinction training to deter relapse. The study investigated the effects of combining treatments of the glycine transporter-1 (GlyT-1) inhibitor, Org24598, with extinction training on the subsequent reacquisition of cocaine self-administration. Squirrel monkeys and rats were trained to self-administer cocaine under a second-order schedule of intravenous drug injection in which responding was maintained by cocaine injections and a cocaine-paired visual stimulus. During three weekly extinction sessions, saline was substituted for cocaine but responding still produced the cocaine-paired stimulus. Subjects were treated with Org24598 or vehicle, either before or after each extinction session.2012-01-01T00:00:00Z2012 Dec2025-04-18T11:54:26.082Z2019-03-27T01:00:37ZS-EPMC34997252294898010.1038/npp.2012.155