{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kamila S"],"funding":["NINDS NIH HHS"],"pagination":["4921-4924"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3501130"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["53(37)"],"pubmed_abstract":["N-Phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines (6a-q) have been synthesized by the Hantzsch thiazole reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones (4a-e) with suitably substituted thioureas using microwave heating. The ethanones (4a-e) were prepared by the reaction of 6-phenylimidazo[2,1-b]thiazoles (3a-e) with chloroacetylchloride in refluxing 1,4-dioxane whereas the thiazoles (3a-e) were synthesized by the reaction of 2-bromo-1-phenylethanones (2a-e) with thiazol-2-amine in refluxing acetone."],"journal":["Tetrahedron letters"],"pubmed_title":["Microwave-assisted Hantzsch thiazole synthesis of N-phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines from the reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones and thioureas."],"pmcid":["PMC3501130"],"funding_grant_id":["RC2 NS069450"],"pubmed_authors":["Mendoza K","Kamila S","Biehl ER"],"additional_accession":[]},"is_claimable":false,"name":"Microwave-assisted Hantzsch thiazole synthesis of N-phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines from the reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones and thioureas.","description":"N-Phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines (6a-q) have been synthesized by the Hantzsch thiazole reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones (4a-e) with suitably substituted thioureas using microwave heating. The ethanones (4a-e) were prepared by the reaction of 6-phenylimidazo[2,1-b]thiazoles (3a-e) with chloroacetylchloride in refluxing 1,4-dioxane whereas the thiazoles (3a-e) were synthesized by the reaction of 2-bromo-1-phenylethanones (2a-e) with thiazol-2-amine in refluxing acetone.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Sep","modification":"2024-11-07T10:18:37.848Z","creation":"2019-03-27T01:00:42Z"},"accession":"S-EPMC3501130","cross_references":{"pubmed":["23175584"],"doi":["10.1016/j.tetlet.2012.06.116"]}}