{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jia Y"],"funding":["National Institutes of Health Grants","NIDDK NIH HHS"],"pagination":["193-207"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3503541"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["129(9-12)"],"pubmed_abstract":["PIMT (also known as PIPMT/NCOA6IP/Tgs1), first isolated as a transcription coactivator PRIP (NCOA6)-interacting 96-kDa protein with RNA-binding property, possesses RNA methyltransferase activity. As a transcription coactivator binding protein, PIMT enhances the nuclear receptor transcriptional activity and its methyltransferase property is involved in the formation of the 2,2,7-trimethylguanosine cap of non-coding small RNAs, but the in vivo functions of this gene have not been fully explored. To elucidate the biological functions, we used gene targeting to generate mice with a disrupted PIMT/Tgs1 gene. Disruption of PIMT gene results in early embryonic lethality due to impairment of development around the blastocyst and uterine implantation stages. We show that PIMT is expressed in all ce"],"journal":["Mechanisms of development"],"pubmed_title":["Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene."],"pmcid":["PMC3503541"],"funding_grant_id":["R01 DK060635","DK083163","R56 DK083163","DK60635","R01 DK083163"],"pubmed_authors":["Viswakarma N","Crawford SE","Jia Y","Karpus WJ","Reddy JK","Zhu YJ","Sarkar J","Kanwar YS","Sambasiva Rao M"],"additional_accession":[]},"is_claimable":false,"name":"Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene.","description":"PIMT (also known as PIPMT/NCOA6IP/Tgs1), first isolated as a transcription coactivator PRIP (NCOA6)-interacting 96-kDa protein with RNA-binding property, possesses RNA methyltransferase activity. As a transcription coactivator binding protein, PIMT enhances the nuclear receptor transcriptional activity and its methyltransferase property is involved in the formation of the 2,2,7-trimethylguanosine cap of non-coding small RNAs, but the in vivo functions of this gene have not been fully explored. To elucidate the biological functions, we used gene targeting to generate mice with a disrupted PIMT/Tgs1 gene. Disruption of PIMT gene results in early embryonic lethality due to impairment of development around the blastocyst and uterine implantation stages. We show that PIMT is expressed in all ce","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Sep-Dec","modification":"2025-04-22T14:25:14.777Z","creation":"2019-06-05T17:53:17Z"},"accession":"S-EPMC3503541","cross_references":{"pubmed":["22982455"],"doi":["10.1016/j.mod.2012.08.002"]}}