{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Siddiq A"],"funding":["Intramural NIH HHS","Cancer Research UK","NICHD NIH HHS","Breast Cancer Now","NIEHS NIH HHS","NHLBI NIH HHS","Medical Research Council","NCI NIH HHS","ZonMw","Wellcome Trust"],"pagination":["5373-84"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3510753"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(24)"],"pubmed_abstract":["Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative subtypes. To identify additional genetic variants for ER-negative breast cancer, we conducted the largest meta-analysis of ER-negative disease to date, comprising 4754 ER-negative cases and 31 663 controls from three GWAS: NCI Breast and Prostate Cancer Cohort Consortium (BPC3) (2188 ER-negative cases; 25 519 controls of European ancestry), Triple Negative Breast Cancer Consortium (TNBCC) (1562 triple negative cases; 3399 controls of European ancestry) and African American Breast Cancer Consortium (AABC) (1004 ER-negative cases; 2745 controls). We performed in silico replication of 86 SNPs at P ≤ 1 × 10(-5) in an add"],"journal":["Human molecular genetics"],"pubmed_title":["A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11."],"pmcid":["PMC3510753"],"funding_grant_id":["R01-CA100598","R01-CA77305","P50 CA089393","N01-HD-3-3175","CA-06-503","R01 HL043851","CA047988","P01 CA087969","U01 CA098233","R01-CA73629","U01-CA98758","U01 CA098710","R25 CA092049","U01-CA98710","R01-CA63464","U01 CA098758","HL080467","R01 CA132839","K24 CA169004","2004NOV49","U01 CA113916","R01 CA120120","R01 CA122340","15106","11022","R37 CA054281","CA122340","CA120120","P30 ES010126","U01 CA069638","5U01CA113916","R37-CA54281","R01 CA073629","R01 CA067262","P50 CA116201","P30 CA016056-32","R01 CA100598","U01 CA049449","P50 CA058223","R01 CA063464","R01 CA054281","U01 CA069631","P30 CA016056","R01 CA065725","P50-CA58223","K01 CA160607","5UO1CA098233","U01-CA69417","HL04385","R01 CA049449","CA 65725","RFA-CA-06-503","G0700491","CA132839","R01-CA100374","U01-CA98216","P30 CA071789","10118","CA67262","U01 CA098216","P30 CA016086","P30-ES10126","CA49449","CA109147","R01 HL080467","U01 CA063464","U01 CA067262","R01 CA077398","R01 CA109147","R01 CA050385","U01 CA69638","91756341","CA87969","R01 CA100374","U01CA69631","U01-CA98233","U01 CA069417","CA116201","CA50385","10124"],"pubmed_authors":["Diver WR","Flesch-Janys D","Southey MC","Feigelson HS","Martin NG","Uitterlinden AG","Hankinson SE","Cross SS","Baglietto L","Chasman DI","Le Marchand L","Apicella C","Palmer JR","Blomqvist C","Easton DF","Waisfisz Q","Ambrosone CB","Fletcher O","Turnbull C","Ekici AB","McLean CA","Buring JE","van Gils CH","Hein R","Weaver J","Zheng W","Chen GK","Hall P","GENICA Consortium","Millikan RC","Peto J","Schmutzler RK","Muller-Myhsok B","Deming SL","Pharoah P","Travis RC","Bernstein L","Hu JJ","Jacobs KB","Kaaks R","Brauch H","Severi G","Ziv E","Gerty SM","Figueroa JD","Van Den Berg D","Monroe KR","Schmidt DF","Ross E","John EM","Riboli E","Miron P","Ridker PM","Overvad K","Bui QM","Ziegler RG","Cox A","Greco D","Rhie SK","Rivadeneira F","Lesnick T","Wilkens LR","Press MF","Fejerman L","Buys SS","Justenhoven C","Henderson BE","Siddiq A","Dunning AM","Huntsman S","Garcia-Closas M","Beckmann L","Berg CD","Schumacher FR","Durcan L","Meijers-Heijboer H","Lee AM","Couch FJ","Tapper WJ","Wang X","Aittomaki K","Wang Z","Ingles SA","Sinn HP","Chanock SJ","Sund M","Chang-Claude J","Gaudet MM","Makalic E","Nickels S","Graham N","Chen C","Park DJ","Fasching PA","Rahman N","Stevens KN","Dos Santos Silva I","Eccles D","Nevanlinna H","Lee IM","Michailidou K","Rodriguez-Gil JL","Kraft P","Palli D","Liu J","Nyante SJ","Vachon CM","Bandera EV","Stone J","Clavel-Chapelon F","Kolonel LN","Hunter DJ","Diasio RB","Irwanto A","Lund E","Schulz-Wendtland R","Isaacs C","Familial Breast Cancer Study","Hoover RN","Thun MJ","Beckmann MW","Giles GG","Godwin AK","Haiman CA","Coetzee GA","Olswold C","Czene K","Australian Breast Cancer Tissue Bank Investigators","Montgomery GW","Pathak H","Hartmann A","Stram DO","Brinton L","Lichtner P","Hopper JL","Lindstrom S","Heinz J","Carpenter JE","Slager S","Amiano P","Campa D","Lathrop M","Meindl A"],"additional_accession":[]},"is_claimable":false,"name":"A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.","description":"Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative subtypes. To identify additional genetic variants for ER-negative breast cancer, we conducted the largest meta-analysis of ER-negative disease to date, comprising 4754 ER-negative cases and 31 663 controls from three GWAS: NCI Breast and Prostate Cancer Cohort Consortium (BPC3) (2188 ER-negative cases; 25 519 controls of European ancestry), Triple Negative Breast Cancer Consortium (TNBCC) (1562 triple negative cases; 3399 controls of European ancestry) and African American Breast Cancer Consortium (AABC) (1004 ER-negative cases; 2745 controls). We performed in silico replication of 86 SNPs at P ≤ 1 × 10(-5) in an add","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Dec","modification":"2026-05-01T07:23:05.816Z","creation":"2026-04-29T03:08:16.539Z"},"accession":"S-EPMC3510753","cross_references":{"pubmed":["22976474"],"doi":["10.1093/hmg/dds381"]}}