biostudies-literatureUnknown8Tigchelaar AIridium-catalyzed intramolecular [4 + 2] cycloadditions of diene-tethered alkynyl halides were investigated by using [IrCl(cod)](2) as catalyst, and dppe was found to be the most suitable phosphine ligand for the reaction. No oxidative insertion of the iridium into the carbon-halide bond was observed, and the reactions proceeded to provide the halogenated cycloadducts in good yield (75-94%). These results are the first examples of cycloadditions of alkynyl halides using an iridium catalyst.Beilstein journal of organic chemistry1765-70https://www.ebi.ac.uk/biostudies/studies/S-EPMC3511010biostudies-literatureIridium-catalyzed intramolecular [4 + 2] cycloadditions of alkynyl halides.PMC3511010Tam WTigchelaar AfalseIridium-catalyzed intramolecular [4 + 2] cycloadditions of alkynyl halides.Iridium-catalyzed intramolecular [4 + 2] cycloadditions of diene-tethered alkynyl halides were investigated by using [IrCl(cod)](2) as catalyst, and dppe was found to be the most suitable phosphine ligand for the reaction. No oxidative insertion of the iridium into the carbon-halide bond was observed, and the reactions proceeded to provide the halogenated cycloadducts in good yield (75-94%). These results are the first examples of cycloadditions of alkynyl halides using an iridium catalyst.2012-01-01T00:00:00Z20122025-05-18T10:44:56.302Z2025-05-18T10:44:56.302ZS-EPMC35110102320951010.3762/bjoc.8.201