{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schneider K"],"funding":["Swiss National Science Foundation"],"pagination":["1138-44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3512403"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(12)"],"pubmed_abstract":["In mammals, transcriptional autorepression by Period (PER) and Cryptochrome (CRY) protein complexes is essential for the generation of circadian rhythms. We have identified CAVIN-3 as a new, cytoplasmic PER2-interacting protein influencing circadian clock properties. Thus, CAVIN-3 loss- and gain-of-function shortened and lengthened, respectively, the circadian period in fibroblasts and affected PER:CRY protein abundance and interaction. While depletion of protein kinase Cδ (PKCδ), a known partner of CAVIN-3, had little effect on circadian gene expression, CAVIN-3 required the PKCδ-binding site to exert its effect on period length. This suggests the involvement of yet uncharacterized protein kinases. Finally, CAVIN-3 activity in circadian gene expression was independent of caveolae."],"journal":["EMBO reports"],"pubmed_title":["CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions."],"pmcid":["PMC3512403"],"funding_grant_id":["128399","113565","128656"],"pubmed_authors":["Kurzchalia T","Schibler U","Gatfield D","Schneider K","Kocher T","Andersin T"],"additional_accession":[]},"is_claimable":false,"name":"CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions.","description":"In mammals, transcriptional autorepression by Period (PER) and Cryptochrome (CRY) protein complexes is essential for the generation of circadian rhythms. We have identified CAVIN-3 as a new, cytoplasmic PER2-interacting protein influencing circadian clock properties. Thus, CAVIN-3 loss- and gain-of-function shortened and lengthened, respectively, the circadian period in fibroblasts and affected PER:CRY protein abundance and interaction. While depletion of protein kinase Cδ (PKCδ), a known partner of CAVIN-3, had little effect on circadian gene expression, CAVIN-3 required the PKCδ-binding site to exert its effect on period length. This suggests the involvement of yet uncharacterized protein kinases. Finally, CAVIN-3 activity in circadian gene expression was independent of caveolae.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Dec","modification":"2025-04-19T12:22:24.339Z","creation":"2019-03-27T01:01:20Z"},"accession":"S-EPMC3512403","cross_references":{"pubmed":["23079727"],"doi":["10.1038/embor.2012.158"]}}