{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Akimova T"],"funding":["NIDDK NIH HHS","NCRR NIH HHS"],"pagination":["3449-61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3513508"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(12)"],"pubmed_abstract":["In a cross-sectional study, we assessed effects of calcineurin inhibitor (CNI) or rapamycin on T-regulatory (Treg) cells from children with stable liver (n = 53) or kidney (n = 9) allografts several years posttransplant. We analyzed Treg number, phenotype, suppressive function, and methylation at the Treg-specific demethylation region (TSDR) using Tregs and peripheral blood mononuclear cells. Forty-eight patients received CNI (39 as monotherapy) and 12 patients received rapamycin (9 as monotherapy). Treg numbers diminished over time on either regimen, but reached significance only with CNI (r =-0.424, p = 0.017). CNI levels inversely correlated with Treg number (r =-0.371, p = 0.026), and positively correlated with CD127+ expression by Tregs (r = 0.437, p = 0.023). Patients with CNI levels"],"journal":["American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"],"pubmed_title":["Differing effects of rapamycin or calcineurin inhibitor on T-regulatory cells in pediatric liver and kidney transplant recipients."],"pmcid":["PMC3513508"],"funding_grant_id":["KO8 1K08DK092282","K08 DK092282","UL1 RR026314","1RC1 DK087270","RC1 DK087270","UL1-RR026314"],"pubmed_authors":["Kamath BM","Bucuvalas JC","Meyers KE","Levine MH","Rand EB","Hancock WW","Hawkins A","Akimova T","Goebel JW"],"additional_accession":[]},"is_claimable":false,"name":"Differing effects of rapamycin or calcineurin inhibitor on T-regulatory cells in pediatric liver and kidney transplant recipients.","description":"In a cross-sectional study, we assessed effects of calcineurin inhibitor (CNI) or rapamycin on T-regulatory (Treg) cells from children with stable liver (n = 53) or kidney (n = 9) allografts several years posttransplant. We analyzed Treg number, phenotype, suppressive function, and methylation at the Treg-specific demethylation region (TSDR) using Tregs and peripheral blood mononuclear cells. Forty-eight patients received CNI (39 as monotherapy) and 12 patients received rapamycin (9 as monotherapy). Treg numbers diminished over time on either regimen, but reached significance only with CNI (r =-0.424, p = 0.017). CNI levels inversely correlated with Treg number (r =-0.371, p = 0.026), and positively correlated with CD127+ expression by Tregs (r = 0.437, p = 0.023). Patients with CNI levels","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Dec","modification":"2025-04-03T23:34:07.83Z","creation":"2019-03-27T01:01:21Z"},"accession":"S-EPMC3513508","cross_references":{"pubmed":["22994804"],"doi":["10.1111/j.1600-6143.2012.04269.x"]}}