{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Villa R"],"funding":["NIGMS NIH HHS"],"pagination":["5396-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3518397"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(21)"],"pubmed_abstract":["The total synthesis of FD-895 was completed through a strategy that featured the use of a tandem esterification ring-closing metathesis (RCM) process to construct the 12-membered macrolide and a modified Stille coupling to append the side chain. These studies combined with detailed analysis of all four possible C16-C17 stereoisomers were used to confirm the structure of FD-895 and identify an analog with an enhanced subnanomolar bioactivity."],"journal":["Organic letters"],"pubmed_title":["Structure of FD-895 revealed through total synthesis."],"pmcid":["PMC3518397"],"funding_grant_id":["R01 GM086225","R01 GM100305","3R01GM086225-01S1"],"pubmed_authors":["Mandel AL","La Clair JJ","Jones BD","Burkart MD","Villa R"],"additional_accession":[]},"is_claimable":false,"name":"Structure of FD-895 revealed through total synthesis.","description":"The total synthesis of FD-895 was completed through a strategy that featured the use of a tandem esterification ring-closing metathesis (RCM) process to construct the 12-membered macrolide and a modified Stille coupling to append the side chain. These studies combined with detailed analysis of all four possible C16-C17 stereoisomers were used to confirm the structure of FD-895 and identify an analog with an enhanced subnanomolar bioactivity.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Nov","modification":"2020-10-29T12:49:36Z","creation":"2019-03-27T01:01:38Z"},"accession":"S-EPMC3518397","cross_references":{"pubmed":["23072504"],"doi":["10.1021/ol3023006"]}}