{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kandadi MR"],"funding":["NCRR NIH HHS","NIGMS NIH HHS"],"pagination":["134"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3520786"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["<h4>Background</h4>Lethal and edema toxins secreted by Bacillus anthracis during anthrax infection were found to incite serious cardiovascular complications. However, the underlying mechanisms in anthrax lethal toxin-induced cardiac anomalies remain unknown. This study was designed to evaluate the impact of antioxidant enzyme catalase in anthrax lethal toxin-induced cardiomyocyte contractile dysfunction.<h4>Methods</h4>Wild type (WT) and cardiac-specific catalase overexpression mice were challenged with lethal toxin (2 μg/g, intraperotineally (i.p.)). Cardiomyocyte contractile and intracellular Ca(2+) properties were assessed 18 h later using an IonOptix edge-detection system. Proteasome function was assessed using chymotrypsin-like and caspase-like activities. GFP-LC3 puncta and Western b"],"journal":["BMC medicine"],"pubmed_title":["Cardiac-specific catalase overexpression rescues anthrax lethal toxin-induced cardiac contractile dysfunction: role of oxidative stress and autophagy."],"pmcid":["PMC3520786"],"funding_grant_id":["5P20 RR016474","8P20 GM103432-12"],"pubmed_authors":["Kandadi MR","Ren J","Yu X","Frankel AE"],"additional_accession":[]},"is_claimable":false,"name":"Cardiac-specific catalase overexpression rescues anthrax lethal toxin-induced cardiac contractile dysfunction: role of oxidative stress and autophagy.","description":"<h4>Background</h4>Lethal and edema toxins secreted by Bacillus anthracis during anthrax infection were found to incite serious cardiovascular complications. However, the underlying mechanisms in anthrax lethal toxin-induced cardiac anomalies remain unknown. This study was designed to evaluate the impact of antioxidant enzyme catalase in anthrax lethal toxin-induced cardiomyocyte contractile dysfunction.<h4>Methods</h4>Wild type (WT) and cardiac-specific catalase overexpression mice were challenged with lethal toxin (2 μg/g, intraperotineally (i.p.)). Cardiomyocyte contractile and intracellular Ca(2+) properties were assessed 18 h later using an IonOptix edge-detection system. Proteasome function was assessed using chymotrypsin-like and caspase-like activities. GFP-LC3 puncta and Western b","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Nov","modification":"2025-04-26T10:47:16.128Z","creation":"2019-03-27T01:01:44Z"},"accession":"S-EPMC3520786","cross_references":{"pubmed":["23134810"],"doi":["10.1186/1741-7015-10-134"]}}