{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Barua D"],"funding":["NIGMS NIH HHS"],"pagination":["e51669"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3524258"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(12)"],"pubmed_abstract":["We present a model of the early events in mast cell signaling mediated by FcεRI where the plasma membrane is composed of many small ordered lipid domains (rafts), surrounded by a non-order region of lipids consisting of the remaining plasma membrane. The model treats the rafts as transient structures that constantly form and breakup, but that maintain a fixed average number per cell. The rafts have a high propensity for harboring Lyn kinase, aggregated, but not unaggregated receptors, and the linker for the activation of T cells (LAT). Phosphatase activity in the rafts is substantially reduced compared to the nonraft region. We use the model to analyze published experiments on the rat basophilic leukemia (RBL)-2H3 cell line that seem to contradict the notion that rafts offer protection. In"],"journal":["PloS one"],"pubmed_title":["A mechanistic model of early FcεRI signaling: lipid rafts and the question of protection from dephosphorylation."],"pmcid":["PMC3524258"],"funding_grant_id":["R37-GM035556","R37 GM035556"],"pubmed_authors":["Goldstein B","Barua D"],"additional_accession":[]},"is_claimable":false,"name":"A mechanistic model of early FcεRI signaling: lipid rafts and the question of protection from dephosphorylation.","description":"We present a model of the early events in mast cell signaling mediated by FcεRI where the plasma membrane is composed of many small ordered lipid domains (rafts), surrounded by a non-order region of lipids consisting of the remaining plasma membrane. The model treats the rafts as transient structures that constantly form and breakup, but that maintain a fixed average number per cell. The rafts have a high propensity for harboring Lyn kinase, aggregated, but not unaggregated receptors, and the linker for the activation of T cells (LAT). Phosphatase activity in the rafts is substantially reduced compared to the nonraft region. We use the model to analyze published experiments on the rat basophilic leukemia (RBL)-2H3 cell line that seem to contradict the notion that rafts offer protection. In","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2025-05-29T22:28:56.447Z","creation":"2025-05-29T22:28:56.447Z"},"accession":"S-EPMC3524258","cross_references":{"pubmed":["23284735"],"doi":["10.1371/journal.pone.0051669"]}}