biostudies-literature00450Kuang YNCI NIH HHSPHS HHS12609-13https://www.ebi.ac.uk/biostudies/studies/S-EPMC3525362biostudies-literatureUnknown18(40)The clean crossed code: Two nitroimidazole-modified thymidines 1 a and 1 b were synthesized and incorporated into DNA oligomers. The 350 nm photolysis of 1 a and 1 b generated a 5-(2'-deoxyuridinyl)methyl radical that induced DNA interstrand cross-links (ICL; see scheme). A higher ICL yield was observed under hypoxic conditions than under aerobic conditions.Chemistry (Weinheim an der Bergstrasse, Germany)Hypoxia-selective DNA interstrand cross-link formation by two modified nucleosides.PMC3525362R15 CA1529141R15A152914-01Peng XBlain JCSun HKuang Y45falseHypoxia-selective DNA interstrand cross-link formation by two modified nucleosides.The clean crossed code: Two nitroimidazole-modified thymidines 1 a and 1 b were synthesized and incorporated into DNA oligomers. The 350 nm photolysis of 1 a and 1 b generated a 5-(2'-deoxyuridinyl)methyl radical that induced DNA interstrand cross-links (ICL; see scheme). A higher ICL yield was observed under hypoxic conditions than under aerobic conditions.2012-01-01T00:00:00Z2012 Oct2024-10-17T17:32:03.453Z2019-03-27T01:01:55ZS-EPMC35253622293639610.1002/chem.201201960