{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kuka M"],"funding":["Intramural NIH HHS"],"pagination":["1223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3528357"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3"],"pubmed_abstract":["An efficient immune response requires coordination between innate and adaptive immunity, which act through cells different in origin and function. Here we report the identification of thymus-derived αβ-T-cell receptor+ cells that express CD11c and major histocompatibility complex class II, and require FLT3 ligand for development (T(DC)). T(DC) express genes heretofore found uniquely in T cells or dendritic cells, as well as a distinctive signature of cytotoxicity-related genes. Unlike other innate T-cell subsets, T(DC) have a polyclonal T-cell receptor repertoire and respond to cognate antigens. However, they differ from conventional T cells in that they do not require help from antigen-presenting cells, respond to Toll-like receptor-mediated stimulation by producing interleukin-12 and pro"],"journal":["Nature communications"],"pubmed_title":["Identification and characterization of polyclonal αβ-T cells with dendritic cell properties."],"pmcid":["PMC3528357"],"funding_grant_id":["ZIA BC010932-05"],"pubmed_authors":["Kuka M","Ashwell JD","Munitic I"],"additional_accession":[]},"is_claimable":false,"name":"Identification and characterization of polyclonal αβ-T cells with dendritic cell properties.","description":"An efficient immune response requires coordination between innate and adaptive immunity, which act through cells different in origin and function. Here we report the identification of thymus-derived αβ-T-cell receptor+ cells that express CD11c and major histocompatibility complex class II, and require FLT3 ligand for development (T(DC)). T(DC) express genes heretofore found uniquely in T cells or dendritic cells, as well as a distinctive signature of cytotoxicity-related genes. Unlike other innate T-cell subsets, T(DC) have a polyclonal T-cell receptor repertoire and respond to cognate antigens. However, they differ from conventional T cells in that they do not require help from antigen-presenting cells, respond to Toll-like receptor-mediated stimulation by producing interleukin-12 and pro","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2025-04-03T23:34:05.457Z","creation":"2019-03-27T01:02:05Z"},"accession":"S-EPMC3528357","cross_references":{"pubmed":["23187623"],"doi":["10.1038/ncomms2223"]}}