biostudies-literatureKuka MIntramural NIH HHS1223https://www.ebi.ac.uk/biostudies/studies/S-EPMC3528357biostudies-literatureUnknown3An efficient immune response requires coordination between innate and adaptive immunity, which act through cells different in origin and function. Here we report the identification of thymus-derived αβ-T-cell receptor+ cells that express CD11c and major histocompatibility complex class II, and require FLT3 ligand for development (T(DC)). T(DC) express genes heretofore found uniquely in T cells or dendritic cells, as well as a distinctive signature of cytotoxicity-related genes. Unlike other innate T-cell subsets, T(DC) have a polyclonal T-cell receptor repertoire and respond to cognate antigens. However, they differ from conventional T cells in that they do not require help from antigen-presenting cells, respond to Toll-like receptor-mediated stimulation by producing interleukin-12 and proNature communicationsIdentification and characterization of polyclonal αβ-T cells with dendritic cell properties.PMC3528357ZIA BC010932-05Kuka MAshwell JDMunitic IfalseIdentification and characterization of polyclonal αβ-T cells with dendritic cell properties.An efficient immune response requires coordination between innate and adaptive immunity, which act through cells different in origin and function. Here we report the identification of thymus-derived αβ-T-cell receptor+ cells that express CD11c and major histocompatibility complex class II, and require FLT3 ligand for development (T(DC)). T(DC) express genes heretofore found uniquely in T cells or dendritic cells, as well as a distinctive signature of cytotoxicity-related genes. Unlike other innate T-cell subsets, T(DC) have a polyclonal T-cell receptor repertoire and respond to cognate antigens. However, they differ from conventional T cells in that they do not require help from antigen-presenting cells, respond to Toll-like receptor-mediated stimulation by producing interleukin-12 and pro2012-01-01T00:00:00Z20122025-04-03T23:34:05.457Z2019-03-27T01:02:05ZS-EPMC35283572318762310.1038/ncomms2223