biostudies-literatureDemarco VGNIA NIH HHSNHLBI NIH HHS159-71https://www.ebi.ac.uk/biostudies/studies/S-EPMC3529378biostudies-literatureUnknown154(1)Obesity and a nondipping circadian blood pressure (BP) pattern are associated with diastolic dysfunction. Ectopic lipid accumulation is increasingly recognized as an important metabolic abnormality contributing to diastolic dysfunction. However, little is known about the contribution of different lipids and the composition of lipid analytes to diastolic dysfunction. We have performed functional and structural studies and analyzed cardiac lipid profile at two time points during progression to diastolic dysfunction in a genetic model of obesity. Serial cardiac magnetic resonance imaging and telemetric measures of BP between 12 and 15 wk of age in obese male db/db mice indicated a nondipping circadian BP pattern and normal diastolic function at 12 wk that progressed to a deteriorating nondippEndocrinologyObesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db mice.PMC3529378R01 HL074214R21 HL111906AG040638HL-074214R03 AG040638HL-73101HL107910R01 HL073101R01 HL107910HL-111906Albert CJHenriksen EJLally JWDemarco VGMa LJohnson MSYang MWhaley-Connell ATFord DAHabibi JFord CAHayden MRSowers JRPrasannarong MAroor ARfalseObesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db mice.Obesity and a nondipping circadian blood pressure (BP) pattern are associated with diastolic dysfunction. Ectopic lipid accumulation is increasingly recognized as an important metabolic abnormality contributing to diastolic dysfunction. However, little is known about the contribution of different lipids and the composition of lipid analytes to diastolic dysfunction. We have performed functional and structural studies and analyzed cardiac lipid profile at two time points during progression to diastolic dysfunction in a genetic model of obesity. Serial cardiac magnetic resonance imaging and telemetric measures of BP between 12 and 15 wk of age in obese male db/db mice indicated a nondipping circadian BP pattern and normal diastolic function at 12 wk that progressed to a deteriorating nondipp2013-01-01T00:00:00Z2013 Jan2025-05-18T11:57:57.224Z2025-05-18T11:57:57.224ZS-EPMC35293782314280810.1210/en.2012-1835