biostudies-literaturePetryk ANCATS NIH HHSNCRR NIH HHSNCI/NIDDKNCI NIH HHSChildren&apos;s Cancer Research Fund467-73https://www.ebi.ac.uk/biostudies/studies/S-EPMC3529966biostudies-literatureUnknown60(3)<h4>Background</h4>Childhood cancer survivors (CCS) are at risk for growth hormone (GH) deficiency. CCS are also at increased risk for early mortality from cardiovascular (CV) disease, but the association between GH levels and CV risk remains poorly understood. The goal of this study was to examine the cross-sectional association between stimulated GH levels and CV risk factors in CCS younger than 18 years.<h4>Procedure</h4>A total of 276 CCS (147 males, 14.4 ± 2.6 years) ≥5 years after cancer diagnosis, and 208 sibling controls (112 males, 13.6 ± 2.4 years) participated in this cross-sectional study, which included anthropometry, body composition, and metabolic studies. Blunted response (BR) was defined as peak GH level <7 µg/L after clonidine and arginine. Insulin sensitivity (M(lbm) ) wPediatric blood & cancerBlunted response to a growth hormone stimulation test is associated with unfavorable cardiovascular risk factor profile in childhood cancer survivors.PMC35299661UL1RR033183M01-RR00400RO1CA113930M01 RR000400UL1 TR000114UL1 RR033183R01 CA113930R01CA113930Steffen LMPerkins JLPetryk AFrohnert BMoran AHodges JSBaker KSChow LZhang LSinaiko ARSteinberger JfalseBlunted response to a growth hormone stimulation test is associated with unfavorable cardiovascular risk factor profile in childhood cancer survivors.<h4>Background</h4>Childhood cancer survivors (CCS) are at risk for growth hormone (GH) deficiency. CCS are also at increased risk for early mortality from cardiovascular (CV) disease, but the association between GH levels and CV risk remains poorly understood. The goal of this study was to examine the cross-sectional association between stimulated GH levels and CV risk factors in CCS younger than 18 years.<h4>Procedure</h4>A total of 276 CCS (147 males, 14.4 ± 2.6 years) ≥5 years after cancer diagnosis, and 208 sibling controls (112 males, 13.6 ± 2.4 years) participated in this cross-sectional study, which included anthropometry, body composition, and metabolic studies. Blunted response (BR) was defined as peak GH level <7 µg/L after clonidine and arginine. Insulin sensitivity (M(lbm) ) w2013-01-01T00:00:00Z2013 Mar2025-04-05T12:54:49.469Z2019-03-27T01:02:11ZS-EPMC35299662300203410.1002/pbc.24308