{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Guirao-Rico S"],"pubmed_abstract":["In Drosophila, the insulin-signaling pathway controls some life history traits, such as fertility and lifespan, and it is considered to be the main metabolic pathway involved in establishing adult body size. Several observations concerning variation in body size in the Drosophila genus are suggestive of its adaptive character. Genes encoding proteins in this pathway are, therefore, good candidates to have experienced adaptive changes and to reveal the footprint of positive selection. The Drosophila insulin-like peptides (DILPs) are the ligands that trigger the insulin-signaling cascade. In Drosophila melanogaster, there are several peptides that are structurally similar to the single mammalian insulin peptide. The footprint of recent adaptive changes on nucleotide variation can be unveiled"],"journal":["PloS one"],"pagination":["e53593"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3538593"],"repository":["biostudies-literature"],"pubmed_title":["Patterns of nucleotide diversity at the regions encompassing the Drosophila insulin-like peptide (dilp) genes: demography vs. positive selection in Drosophila melanogaster."],"pmcid":["PMC3538593"],"pubmed_authors":["Guirao-Rico S","Aguade M"],"additional_accession":[]},"is_claimable":false,"name":"Patterns of nucleotide diversity at the regions encompassing the Drosophila insulin-like peptide (dilp) genes: demography vs. positive selection in Drosophila melanogaster.","description":"In Drosophila, the insulin-signaling pathway controls some life history traits, such as fertility and lifespan, and it is considered to be the main metabolic pathway involved in establishing adult body size. Several observations concerning variation in body size in the Drosophila genus are suggestive of its adaptive character. Genes encoding proteins in this pathway are, therefore, good candidates to have experienced adaptive changes and to reveal the footprint of positive selection. The Drosophila insulin-like peptides (DILPs) are the ligands that trigger the insulin-signaling cascade. In Drosophila melanogaster, there are several peptides that are structurally similar to the single mammalian insulin peptide. The footprint of recent adaptive changes on nucleotide variation can be unveiled","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2026-04-15T19:28:35.378Z","creation":"2019-03-26T23:19:20Z"},"accession":"S-EPMC3538593","cross_references":{"pubmed":["23308258"],"doi":["10.1371/journal.pone.0053593"]}}