{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Sgourou A"],"pubmed_abstract":["BACKGROUND: The aim of this study was to determine the genotype distribution and allelic frequencies of ACE (I/D), AGTR1 (A +1166 C), BDKRB2 (+9/-9) and LEP (G-2548A) genomic variations in 175 Greek athletes who excelled at a national and/or international level and 169 healthy Greek adults to identify whether some particular combinations of these loci might serve as predictive markers for superior physical condition. RESULTS: The D/D genotype of the ACE gene (p = 0.034) combined with the simultaneous existence of BDKRB2 (+9/-9) (p = 0.001) or LEP (G/A) (p = 0.021) genotypes was the most prevalent among female athletes compared to female controls. A statistical trend was also observed in BDKRB2 (+9/-9) and LEP (G-2548A) heterozygous genotypes among male and female Greek athletes, and in ACE (I/D) only in male athletes. Finally, both male and female athletes showed the highest rates in the AGTR1 (A/A) genotype. CONCLUSIONS: Our results suggest that the co-existence of ACE (D/D), BDKRB2 (+9/-9) or LEP (G/A) genotypes in female athletes might be correlated with a superior level of physical performance."],"journal":["Human genomics"],"pagination":["24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3543191"],"repository":["biostudies-literature"],"pubmed_title":["Association of genome variations in the renin-angiotensin system with physical performance."],"pmcid":["PMC3543191"],"pubmed_authors":["Fotopoulos V","Sgourou A","Kontos V","Papachatzopoulou A","Patrinos GP"],"additional_accession":[]},"is_claimable":false,"name":"Association of genome variations in the renin-angiotensin system with physical performance.","description":"BACKGROUND: The aim of this study was to determine the genotype distribution and allelic frequencies of ACE (I/D), AGTR1 (A +1166 C), BDKRB2 (+9/-9) and LEP (G-2548A) genomic variations in 175 Greek athletes who excelled at a national and/or international level and 169 healthy Greek adults to identify whether some particular combinations of these loci might serve as predictive markers for superior physical condition. RESULTS: The D/D genotype of the ACE gene (p = 0.034) combined with the simultaneous existence of BDKRB2 (+9/-9) (p = 0.001) or LEP (G/A) (p = 0.021) genotypes was the most prevalent among female athletes compared to female controls. A statistical trend was also observed in BDKRB2 (+9/-9) and LEP (G-2548A) heterozygous genotypes among male and female Greek athletes, and in ACE (I/D) only in male athletes. Finally, both male and female athletes showed the highest rates in the AGTR1 (A/A) genotype. CONCLUSIONS: Our results suggest that the co-existence of ACE (D/D), BDKRB2 (+9/-9) or LEP (G/A) genotypes in female athletes might be correlated with a superior level of physical performance.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2021-02-19T22:13:36Z","creation":"2019-06-05T18:05:57Z"},"accession":"S-EPMC3543191","cross_references":{"pubmed":["23176367"],"doi":["10.1186/1479-7364-6-24"]}}