{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Parks BW"],"funding":["NICHD NIH HHS","NIDDK NIH HHS","Howard Hughes Medical Institute","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["141-52"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3545283"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Obesity is a highly heritable disease driven by complex interactions between genetic and environmental factors. Human genome-wide association studies (GWAS) have identified a number of loci contributing to obesity; however, a major limitation of these studies is the inability to assess environmental interactions common to obesity. Using a systems genetics approach, we measured obesity traits, global gene expression, and gut microbiota composition in response to a high-fat/high-sucrose (HF/HS) diet of more than 100 inbred strains of mice. Here we show that HF/HS feeding promotes robust, strain-specific changes in obesity that are not accounted for by food intake and provide evidence for a genetically determined set point for obesity. GWAS analysis identified 11 genome-wide significant loci associated with obesity traits, several of which overlap with loci identified in human studies. We also show strong relationships between genotype and gut microbiota plasticity during HF/HS feeding and identify gut microbial phylotypes associated with obesity."],"journal":["Cell metabolism"],"pubmed_title":["Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice."],"pmcid":["PMC3545283"],"funding_grant_id":["HL30568","P01 HL030568","T32 GM142607","T32 HD007228","DK094311","HL028481","T32 GM008759","T32-GM08759","R00 HL102223","T32-HL69766","DP3 DK094311","P01 HL028481","T32-HD07228","T32 HL069766"],"pubmed_authors":["Rau CD","Norheim F","Mehrabian M","Nam E","Org E","Eskin E","Kostem E","Bennett BJ","Kirby M","Drake TA","Knight R","Drevon CA","Civelek M","Pan C","Parks BW","Castellani LW","Hui ST","Ursell LK","Kirchgessner T","Lusis AJ","Zinker B","He A","Gargalovic P"],"additional_accession":[]},"is_claimable":false,"name":"Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice.","description":"Obesity is a highly heritable disease driven by complex interactions between genetic and environmental factors. Human genome-wide association studies (GWAS) have identified a number of loci contributing to obesity; however, a major limitation of these studies is the inability to assess environmental interactions common to obesity. Using a systems genetics approach, we measured obesity traits, global gene expression, and gut microbiota composition in response to a high-fat/high-sucrose (HF/HS) diet of more than 100 inbred strains of mice. Here we show that HF/HS feeding promotes robust, strain-specific changes in obesity that are not accounted for by food intake and provide evidence for a genetically determined set point for obesity. GWAS analysis identified 11 genome-wide significant loci associated with obesity traits, several of which overlap with loci identified in human studies. We also show strong relationships between genotype and gut microbiota plasticity during HF/HS feeding and identify gut microbial phylotypes associated with obesity.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Jan","modification":"2026-04-30T07:31:28.493Z","creation":"2026-04-07T15:53:04.96Z"},"accession":"S-EPMC3545283","cross_references":{"pubmed":["23312289"],"doi":["10.1016/j.cmet.2012.12.007"]}}