biostudies-literatureRay LANCRR NIH HHSNIAAA NIH HHSE116-24https://www.ebi.ac.uk/biostudies/studies/S-EPMC3548029biostudies-literatureUnknown37 Suppl 1<h4>Background</h4>Subjective response to alcohol has been examined as a marker of alcoholism risk. The A118G single-nucleotide polymorphism (SNP) of the mu-opioid receptor (OPRM1) gene has been previously associated with subjective response to alcohol in heavy drinkers. This study seeks to extend the literature by examining the effect of OPRM1 genotype on responses to alcohol in a sample of alcohol-dependent individuals. A secondary aim of this study is to examine alcoholism severity as a predictor of subjective responses to alcohol.<h4>Methods</h4>Nontreatment seeking problem drinkers (n = 295) were assessed in the laboratory for clinical dimensions of alcohol dependence. Following prospective genotyping, 43 alcohol-dependent individuals across the 2 genotype conditions (AA, n = 23 and AAlcoholism, clinical and experimental researchSubjective response to alcohol among alcohol-dependent individuals: effects of the μ-opioid receptor (OPRM1) gene and alcoholism severity.PMC3548029K23 AA016936K05 AA019681R03 AA019569M01 RR000865M01-RR00865Ray LABujarski SMacKillop JMonti PMMiotto KCourtney KEfalseSubjective response to alcohol among alcohol-dependent individuals: effects of the μ-opioid receptor (OPRM1) gene and alcoholism severity.<h4>Background</h4>Subjective response to alcohol has been examined as a marker of alcoholism risk. The A118G single-nucleotide polymorphism (SNP) of the mu-opioid receptor (OPRM1) gene has been previously associated with subjective response to alcohol in heavy drinkers. This study seeks to extend the literature by examining the effect of OPRM1 genotype on responses to alcohol in a sample of alcohol-dependent individuals. A secondary aim of this study is to examine alcoholism severity as a predictor of subjective responses to alcohol.<h4>Methods</h4>Nontreatment seeking problem drinkers (n = 295) were assessed in the laboratory for clinical dimensions of alcohol dependence. Following prospective genotyping, 43 alcohol-dependent individuals across the 2 genotype conditions (AA, n = 23 and A2013-01-01T00:00:00Z2013 Jan2025-04-04T19:38:24.097Z2019-03-27T01:03:26ZS-EPMC35480292324071110.1111/j.1530-0277.2012.01916.x