biostudies-literatureUnknown3(1)Weiss EA<h4>Objective</h4>To determine if there is a significant difference in the infection rates of wounds irrigated with sterile normal saline (SS) versus tap water (TW), before primary wound closure.<h4>Design</h4>Single centre, prospective, randomised, double-blind controlled trial. Wound irrigation solution type was computer randomised and allocation was done on a sequential basis.<h4>Setting</h4>Stanford University Medical Center Department of Emergency Medicine.<h4>Participants</h4>Patients older than 1 year of age, who presented to the emergency department with a soft tissue laceration requiring repair, were entered into the study under informed consent. Exclusion criteria included any underlying immunocompromising illness, current use of antibiotics, puncture or bite wounds, underlying tBMJ opene001504https://www.ebi.ac.uk/biostudies/studies/S-EPMC3549228biostudies-literatureWater is a safe and effective alternative to sterile normal saline for wound irrigation prior to suturing: a prospective, double-blind, randomised, controlled clinical trial.PMC3549228Weiss EAQuinn JVOldham GLin MFoster TfalseWater is a safe and effective alternative to sterile normal saline for wound irrigation prior to suturing: a prospective, double-blind, randomised, controlled clinical trial.<h4>Objective</h4>To determine if there is a significant difference in the infection rates of wounds irrigated with sterile normal saline (SS) versus tap water (TW), before primary wound closure.<h4>Design</h4>Single centre, prospective, randomised, double-blind controlled trial. Wound irrigation solution type was computer randomised and allocation was done on a sequential basis.<h4>Setting</h4>Stanford University Medical Center Department of Emergency Medicine.<h4>Participants</h4>Patients older than 1 year of age, who presented to the emergency department with a soft tissue laceration requiring repair, were entered into the study under informed consent. Exclusion criteria included any underlying immunocompromising illness, current use of antibiotics, puncture or bite wounds, underlying t2013-01-01T00:00:00Z2013 Jan2026-04-13T13:29:30.375Z2019-03-27T01:03:31ZS-EPMC35492282332589610.1136/bmjopen-2012-001504