{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Towner RA"],"funding":["NCRR NIH HHS","NIAMS NIH HHS"],"pagination":["77-90; discussion 91"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3555701"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72(1)"],"pubmed_abstract":["<h4>Background</h4>Glioblastoma multiforme (GBM), a high-grade glioma, is characterized by being diffuse, invasive, and highly angiogenic and has a very poor prognosis. Identification of new biomarkers could help in the further diagnosis of GBM.<h4>Objective</h4>To identify ELTD1 (epidermal growth factor, latrophilin, and 7 transmembrane domain-containing protein 1 on chromosome 1) as a putative glioma-associated marker via a bioinformatic method.<h4>Methods</h4>We used advanced data mining and a novel bioinformatics method to predict ELTD1 as a potential novel biomarker that is associated with gliomas. Validation was done with immunohistochemistry, which was used to detect levels of ELTD1 in human high-grade gliomas and rat F98 glioma tumors. In vivo levels of ELTD1 in rat F98 gliomas wer"],"journal":["Neurosurgery"],"pubmed_title":["ELTD1, a potential new biomarker for gliomas."],"pmcid":["PMC3555701"],"funding_grant_id":["P20 RR020143","AR092-049","5P20RR020143-07"],"pubmed_authors":["Lupu F","Smith N","Saunders D","Towner RA","Giles CB","Vaillant B","Casteel R","Gillespie DL","Colman H","Silasi-Mansat R","Jensen RL","Wren JD"],"additional_accession":[]},"is_claimable":false,"name":"ELTD1, a potential new biomarker for gliomas.","description":"<h4>Background</h4>Glioblastoma multiforme (GBM), a high-grade glioma, is characterized by being diffuse, invasive, and highly angiogenic and has a very poor prognosis. Identification of new biomarkers could help in the further diagnosis of GBM.<h4>Objective</h4>To identify ELTD1 (epidermal growth factor, latrophilin, and 7 transmembrane domain-containing protein 1 on chromosome 1) as a putative glioma-associated marker via a bioinformatic method.<h4>Methods</h4>We used advanced data mining and a novel bioinformatics method to predict ELTD1 as a potential novel biomarker that is associated with gliomas. Validation was done with immunohistochemistry, which was used to detect levels of ELTD1 in human high-grade gliomas and rat F98 glioma tumors. In vivo levels of ELTD1 in rat F98 gliomas wer","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Jan","modification":"2025-04-26T19:56:45.028Z","creation":"2019-03-27T01:03:51Z"},"accession":"S-EPMC3555701","cross_references":{"pubmed":["23096411"],"doi":["10.1227/NEU.0b013e318276b29d","10.1227/neu.0b013e318276b29d"]}}