biostudies-literatureTowner RANCRR NIH HHSNIAMS NIH HHS77-90; discussion 91https://www.ebi.ac.uk/biostudies/studies/S-EPMC3555701biostudies-literatureUnknown72(1)<h4>Background</h4>Glioblastoma multiforme (GBM), a high-grade glioma, is characterized by being diffuse, invasive, and highly angiogenic and has a very poor prognosis. Identification of new biomarkers could help in the further diagnosis of GBM.<h4>Objective</h4>To identify ELTD1 (epidermal growth factor, latrophilin, and 7 transmembrane domain-containing protein 1 on chromosome 1) as a putative glioma-associated marker via a bioinformatic method.<h4>Methods</h4>We used advanced data mining and a novel bioinformatics method to predict ELTD1 as a potential novel biomarker that is associated with gliomas. Validation was done with immunohistochemistry, which was used to detect levels of ELTD1 in human high-grade gliomas and rat F98 glioma tumors. In vivo levels of ELTD1 in rat F98 gliomas werNeurosurgeryELTD1, a potential new biomarker for gliomas.PMC3555701P20 RR020143AR092-0495P20RR020143-07Lupu FSmith NSaunders DTowner RAGiles CBVaillant BCasteel RGillespie DLColman HSilasi-Mansat RJensen RLWren JDfalseELTD1, a potential new biomarker for gliomas.<h4>Background</h4>Glioblastoma multiforme (GBM), a high-grade glioma, is characterized by being diffuse, invasive, and highly angiogenic and has a very poor prognosis. Identification of new biomarkers could help in the further diagnosis of GBM.<h4>Objective</h4>To identify ELTD1 (epidermal growth factor, latrophilin, and 7 transmembrane domain-containing protein 1 on chromosome 1) as a putative glioma-associated marker via a bioinformatic method.<h4>Methods</h4>We used advanced data mining and a novel bioinformatics method to predict ELTD1 as a potential novel biomarker that is associated with gliomas. Validation was done with immunohistochemistry, which was used to detect levels of ELTD1 in human high-grade gliomas and rat F98 glioma tumors. In vivo levels of ELTD1 in rat F98 gliomas wer2013-01-01T00:00:00Z2013 Jan2025-04-26T19:56:45.028Z2019-03-27T01:03:51ZS-EPMC35557012309641110.1227/NEU.0b013e318276b29d10.1227/neu.0b013e318276b29d