{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin G"],"funding":["NCI NIH HHS"],"pagination":["95-101"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3556942"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Background
Percentage of free-to-total prostate-specific antigen (%fPSA) is an independent predictor of risk for prostate cancer among men with modestly elevated level of total PSA (tPSA) in blood. Physiological and pathological factors have been shown to influence the %fPSA value and diagnostic accuracy.Materials/methods
To evaluate genetic determinants of %fPSA, we conducted a genome-wide association study of serum %fPSA by genotyping 642,584 single nucleotide polymorphisms (SNPs) in 3192 men of European ancestry, each with a tPSA level of 2.5 to 10 ng/ml, that were recruited in the REduction by DUtasteride of Prostate Cancer Events study. Single nucleotide polymorphisms (SNPs) with P < 10(-5) were further evaluated among the controls of a population-based case-control st"],"journal":["Neoplasia (New York, N.Y.)"],"pubmed_title":["Genome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA."],"pmcid":["PMC3556942"],"funding_grant_id":["P50 CA092629","UC2 CA148463","RC2 CA148463","P50-CA92629","R33 CA 127768-02","R33 CA127768"],"pubmed_authors":["Zheng SL","Isaacs WB","Lilja H","Kim ST","Gronberg H","Xu J","Jin G","Young T","Feng J","Condreay LD","Tao S","Gao Z","Wiklund F","Rittmaster RS","Sun J"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA.","description":"Background
Percentage of free-to-total prostate-specific antigen (%fPSA) is an independent predictor of risk for prostate cancer among men with modestly elevated level of total PSA (tPSA) in blood. Physiological and pathological factors have been shown to influence the %fPSA value and diagnostic accuracy.Materials/methods
To evaluate genetic determinants of %fPSA, we conducted a genome-wide association study of serum %fPSA by genotyping 642,584 single nucleotide polymorphisms (SNPs) in 3192 men of European ancestry, each with a tPSA level of 2.5 to 10 ng/ml, that were recruited in the REduction by DUtasteride of Prostate Cancer Events study. Single nucleotide polymorphisms (SNPs) with P < 10(-5) were further evaluated among the controls of a population-based case-control st","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Jan","modification":"2026-05-01T07:09:59.934Z","creation":"2026-04-07T16:42:16.773Z"},"accession":"S-EPMC3556942","cross_references":{"pubmed":["23359319"],"doi":["10.1593/neo.121620"]}}